Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893)
A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With Hematologic Malignancies
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).
Who can join: Review the eligibility criteria below.
Location: Highlands Oncology Group ( Site 2728) — Springdale, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (121 Sites)
Showing the first 25 of 121 sites.
- Highlands Oncology Group ( Site 2728) — Springdale, Arkansas
- University of California San Diego Moores Cancer Center ( Site 2717) — La Jolla, California
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724) — Torrance, California
- Colorado Blood Cancer Institute ( Site 2726) — Denver, Colorado
- The University of Louisville, James Graham Brown Cancer Center ( Site 2729) — Louisville, Kentucky
- Mayo Clinic - Rochester ( Site 2706) — Rochester, Minnesota
- Astera Cancer Care ( Site 2732) — East Brunswick, New Jersey
- John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704) — Hackensack, New Jersey
- Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708) — Fargo, North Dakota
- UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730) — Dallas, Texas
- Medical Oncology Associates (Summit Cancer Centers) ( Site 2710) — Spokane, Washington
- Hospital Aleman ( Site 0102) — Ciudad Autonoma de Buenos Aires, Buenos Aires
- Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103) — Buenos Aires, Buenos Aires F.D.
- Fundacion Estudios Clinicos ( Site 0112) — Rosario, Santa Fe Province
- FUNDALEU ( Site 0104) — Caba,
- Hospital Privado Universitario de Córdoba ( Site 0107) — Córdoba,
- Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110) — Mendoza,
- Nepean Hospital-Nepean Cancer Care Centre ( Site 0204) — Sydney, New South Wales
- Box Hill Hospital ( Site 0203) — Box Hill, Victoria
- Sir Charles Gairdner Hospital ( Site 0200) — Nedlands, Western Australia
- Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303) — São Paulo, São Paulo
- Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300) — Rio de Janeiro,
- BP - A Beneficencia Portuguesa de São Paulo ( Site 0302) — São Paulo,
- Hospital Paulistano - Amil Clinical Research ( Site 0311) — São Paulo,
- Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401) — Calgary, Alberta
📞 Contact the Study Coordinator
Phone: (888) 577-8839
Email: Trialsites@msd.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hematologic Malignancies
- Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation — New York, New York
- A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies — San Francisco, California
- Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device — Milwaukee, Wisconsin
- A Study of Ruxolitinib for Preventing Graft-Versus-Host Disease in People With a Hematologic Malignancy Who Will Receive a Stem Cell Transplant — Basking Ridge, New Jersey
- Digital Health Intervention for Self-Management and Telemonitoring in Chimeric Antigen Receptor (CAR-T) Therapy — Duarte, California
- PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV) — Duarte, California
Explore by condition: All Hematologic Malignancies clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.