🏛️ Verified NIH Record • Updated 2026-08-20

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893)

A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With Hematologic Malignancies

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).

Who can join: Review the eligibility criteria below.

Location: Highlands Oncology Group ( Site 2728) — Springdale, Arkansas

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (121 Sites)

Showing the first 25 of 121 sites.

  • Highlands Oncology Group ( Site 2728) — Springdale, Arkansas
  • University of California San Diego Moores Cancer Center ( Site 2717) — La Jolla, California
  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724) — Torrance, California
  • Colorado Blood Cancer Institute ( Site 2726) — Denver, Colorado
  • The University of Louisville, James Graham Brown Cancer Center ( Site 2729) — Louisville, Kentucky
  • Mayo Clinic - Rochester ( Site 2706) — Rochester, Minnesota
  • Astera Cancer Care ( Site 2732) — East Brunswick, New Jersey
  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704) — Hackensack, New Jersey
  • Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708) — Fargo, North Dakota
  • UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730) — Dallas, Texas
  • Medical Oncology Associates (Summit Cancer Centers) ( Site 2710) — Spokane, Washington
  • Hospital Aleman ( Site 0102) — Ciudad Autonoma de Buenos Aires, Buenos Aires
  • Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103) — Buenos Aires, Buenos Aires F.D.
  • Fundacion Estudios Clinicos ( Site 0112) — Rosario, Santa Fe Province
  • FUNDALEU ( Site 0104) — Caba,
  • Hospital Privado Universitario de Córdoba ( Site 0107) — Córdoba,
  • Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110) — Mendoza,
  • Nepean Hospital-Nepean Cancer Care Centre ( Site 0204) — Sydney, New South Wales
  • Box Hill Hospital ( Site 0203) — Box Hill, Victoria
  • Sir Charles Gairdner Hospital ( Site 0200) — Nedlands, Western Australia
  • Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303) — São Paulo, São Paulo
  • Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300) — Rio de Janeiro,
  • BP - A Beneficencia Portuguesa de São Paulo ( Site 0302) — São Paulo,
  • Hospital Paulistano - Amil Clinical Research ( Site 0311) — São Paulo,
  • Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401) — Calgary, Alberta

📞 Contact the Study Coordinator

Phone: (888) 577-8839

Email: Trialsites@msd.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗