A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML (NCT04730258)
Phase 1b/2 Clinical Study of the Safety, Tolerability, and Pharmacokinetic and Pharmacodynamic Profiles of CFI-400945 as a Single Agent or in Combination With Azacitidine in Patients With AML, MDS or CMML
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to test the safety of an investigational drug called CFI-400945 alone and in combination with azacitidine.
Who can join: Review the eligibility criteria below.
Location: City of Hope — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- City of Hope — Duarte, California
- University of California Davis Comprehensive Cancer Center — Sacramento, California
- Norton Cancer Institute - Saint Matthews — Louisville, Kentucky
- New York Presbyterian Weill Cornell Medical Center — New York, New York
- The Ohio State University Comprehensive Cancer Center — Columbus, Ohio
- The University of Texas MD Anderson Cancer Centre — Houston, Texas
- University of Alberta — Edmonton, Alberta
- Princess Margaret Cancer Center — Toronto, Ontario
- Queen Mary Hospital — Hong Kong,
📞 Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.