A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity. (NCT04752774)
An Integrated Phase I/II, Multicentre, Double-blind, Randomised, Dysport and Placebo-controlled, Dose Escalation and Dose-finding Study to Evaluate the Safety and Efficacy of IPN10200 in the Treatment of Adult Upper Limb Spasticity.
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total Corabotase doses(s) that offer the best efficacy/safety profile when used for the treatment of Adult upper limb (AUL) spasticity.
Who can join: Review the eligibility criteria below.
Location: Rancho Los Amigos National Rehab — Downey, California
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (81 Sites)
Showing the first 25 of 81 sites.
- Rancho Los Amigos National Rehab — Downey, California
- Kansas Institute of Research — Overland Park, Kansas
- Quest Research Institute — Farmington Hills, Michigan
- Einstein Physical Medicine and Rehabilitation at Elkins Park — Elkins Park, Pennsylvania
- The University of Texas Southwestern Medical Center — Dallas, Texas
- Medical University Innsbruck, Department of Neurology — Innsbruck,
- Kepler University Hospital GmbH, Department of Neurology and Psychiatry — Linz,
- Brothers of Charity Hospital Linz, Department of Neurology I — Linz,
- Medical University Vienna, Department of Neurology — Vienna,
- Multiprofile Hospital for Active Treatment "Heart and Brain" — Pleven,
- Medical Center "Rusemed" EOOD — Rousse,
- Multiprofile Hospital for Active Treatment of Neurology and Psychiatry "Sveti Naum", Sofia, Neurological Diseases Clinic for Neurodegenerative and Peripheral Neurological Diseases — Sofia,
- Diagnostic Consulting Center - Convex EOOD — Sofia,
- Medical Center Medica Plus Ltd — Veliko Tarnovo,
- University Hospital Hradec Kralove, Clinic of Neurology — Hradec Králové,
- Hospital Jihlava, Department of Neurology — Jihlava,
- University Hospital Ostrava, Clinic of Neurology, Center for Demyelinating diseases — Ostrava,
- Regional Hospital Pardubice, Clinic of Neurology — Pardubice,
- University Hospital Kralovske Vinohrady, Clinic of Neurology — Prague,
- General University Hospital in Prague, Clinic of Neurology — Prague,
- Bastia Hospital Center — Bastia,
- Bordeaux University Hospital Center - Pellegrin Hospital Group — Bordeaux,
- Brest University Hospital Center - Morvan Hospital — Brest,
- Raymond-Poincare Hospital - APHP — Garches,
- University Hospital Bonn, Clinic and Policlinic for Neurology — Bonn,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.