🏛️ Verified NIH Record • Updated 2026-06-02
Tumor-induced Osteomalacia Disease Monitoring Program (NCT04783428)
Tumor-induced Osteomalacia Disease Monitoring Program (TIO DMP)
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Ultragenyx Pharmaceutical Inc
🩺 Plain-English Summary (8th-Grade Level)
The objectives of this observational study are to assess the long-term safety and long-term effectiveness of burosumab in patients with TIO who are being treated with burosumab as prescribed by their physician and to monitor the course of the underlying phosphaturic mesenchymal tumor (PMT) overtime in patients with TIO irrespective of their treatment status.
Who can join: Review the eligibility criteria below.
Location: Yale University — New Haven, Connecticut
🧪 Interventions in This Study
- No intervention (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (6 Sites)
- Yale University — New Haven, Connecticut
- Indiana University — Bloomington, Indiana
- Johns Hopkins University — Baltimore, Maryland
- Vanderbilt University Medical Center — Nashville, Tennessee
- University of Virginia — Charlottesville, Virginia
- IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas — Buenos Aires,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Tumor-induced Osteomalacia (TIO) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.