Early Prediction of Preeclampsia Using arteriaL Stiffness in High-risk prEgnancies (NCT04783597)
Early Prediction of Preeclampsia Using arteriaL Stiffness in High-risk prEgnancies; a Multinational Study (PULSE)
🩺 Plain-English Summary (8th-Grade Level)
Despite advances in obstetric care, preeclampsia (PE) remains the leading cause of maternal death and disability in both developed and developing countries, contributing to over 70,000 maternal and 500,000 fetal deaths annually worldwide. PULSE was designed using a preventative medicine approach, focusing on improving early detection of PE as opposed to managing symptoms after onset. The study aims to uncover the earliest possible signs of PE using a combination of novel clinical tools and established diagnostic techniques to better identify, track, and manage high risk pregnant women. Specifically, PULSE will be examining the incorporation of a non-invasive test for the measurement of arterial stiffness, which has been shown to be predictive of hypertensive disorders. This test, in combination with a wide range of blood biomarkers, detailed ultrasound imaging, and a comprehensive battery of physical and mental health questionnaires, represents the largest, most comprehensive preventative PE study to date. The results of this work has the potential to revolutionize the way PE and other hypertensive disorders of pregnancy are managed and treated and can serve to inform the design of future preventative clinical research studies.
Who can join: Review the eligibility criteria below.
Location: Royal Victoria Hospital — Montreal, Quebec
Age range: 18 Years
🧪 Interventions in This Study
- Arterial Stiffness and Wave Reflection (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Royal Victoria Hospital — Montreal, Quebec
📞 Contact the Study Coordinator
Phone: (514) 934-1934
Email: helena.papacostas@rimuhc.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in High Risk Pregnancy
- Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise — Madison, Wisconsin
- IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy — New York, New York
- Remote Fetal Monitoring in High Risk Pregnancies — Boston, Massachusetts
Explore by condition: All High Risk Pregnancy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.