๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-14

Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC (NCT04821622)

TALAPRO-3: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, STUDY OF TALAZOPARIB WITH ENZALUTAMIDE VERSUS PLACEBO WITH ENZALUTAMIDE IN MEN WITH DDR GENE MUTATED METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Pfizer

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of the study is to evaluate the safety and efficacy of talazoparib in combination with enzalutamide compared with placebo in combination with enzalutamide in participants with DDR-deficient mCSPC.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham โ€” Birmingham, Alabama

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (313 Sites)

Showing the first 25 of 313 sites.

  • University of Alabama at Birmingham โ€” Birmingham, Alabama
  • University of Alabama at Birmingham โ€” Birmingham, Alabama
  • Arizona Institute of Urology, PLLC โ€” Tucson, Arizona
  • Beverly Hills Cancer Center โ€” Beverly Hills, California
  • Adventist Health Glendale โ€” Glendale, California
  • VA Long Beach Healthcare System โ€” Long Beach, California
  • Yale-New Haven Hospital โ€” New Haven, Connecticut
  • MedStar Georgetown University Hospital โ€” Washington D.C., District of Columbia
  • Washington Cancer Institute at MedStar Washington Hospital Center โ€” Washington D.C., District of Columbia
  • AdventHealth Medical Group Hematology and Oncology โ€” Orlando, Florida
  • Investigational Drug Services, Advent Health Orlando โ€” Orlando, Florida
  • Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital โ€” Austell, Georgia
  • Wellstar Cobb Hospital โ€” Austell, Georgia
  • Northwest Georgia Oncology Centers, a Service of Tanner Medical Center Villa Rica โ€” Carrollton, Georgia
  • West Georgia Infusion Center, a Service of Tanner Medical Center Villa Rica โ€” Carrollton, Georgia
  • Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital โ€” Cartersville, Georgia
  • Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital โ€” Douglasville, Georgia
  • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital โ€” Marietta, Georgia
  • Comprehensive Urologic Care, SC โ€” Lake Barrington, Illinois
  • Mid-Illinois Hematology & Oncology Associates, Ltd โ€” Normal, Illinois
  • Henry Ford Health System โ€” Detroit, Michigan
  • Henry Ford Medical Center - New Center One โ€” Detroit, Michigan
  • Revive Research Institute, Inc. โ€” Farmington Hills, Michigan
  • David C. Pratt Cancer Center โ€” St Louis, Missouri
  • New Jersey Cancer Care, P.A. โ€” Belleville, New Jersey

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Prostate Cancer clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—