🏛️ Verified NIH Record • Updated 2026-03-04
Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial (NCT04835506)
🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Beth Israel Deaconess Medical Center
🩺 Plain-English Summary (8th-Grade Level)
The OPTIMIZE Trial compares whether iDose dashboard-driven infliximab dosing (iDose-driven dosing) is more effective and safer than standard infliximab dosing for inducing and maintaining disease remission in inflammatory bowel disease.
Who can join: Review the eligibility criteria below.
Location: Yale University School of Medicine — New Haven, Connecticut
Age range: 16 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (25 Sites)
- Yale University School of Medicine — New Haven, Connecticut
- University of Miami — Miami, Florida
- University of Chicago Medicine — Chicago, Illinois
- Northwestern University — Evanston, Illinois
- Rockford GI — Rockford, Illinois
- University of Maryland Medical Center — Baltimore, Maryland
- Boston Children's Hospital — Boston, Massachusetts
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- Lahey Hospital and Medical Center — Burlington, Massachusetts
- University of Minnesota — Minneapolis, Minnesota
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire
- NYU Langone Health — New York, New York
- Icahn School of Medicine at Mount Sinai — New York, New York
- Weill Cornell Medical College — New York, New York
- Atrium Health Center for Digestive Health — Charlotte, North Carolina
- Cleveland Clinic — Cleveland, Ohio
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania
- LifeSpan Brown University — Providence, Rhode Island
- Medical University of South Carolina — Charleston, South Carolina
- Vanderbilt University Medical Center — Nashville, Tennessee
- University of Texas Southwestern Medical Center — Dallas, Texas
- University of Utah — Salt Lake City, Utah
- Medical College of Wisconsin — Milwaukee, Wisconsin
- London Health Sciences Centre - Children's Hospital — London,
- McGill University Health Centre (MUHC) Montreal General Hospital — Montreal,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.