Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma (NCT04850846)
A Randomized Placebo-Controlled Phase 2 Study of Metformin for the Prevention of Progression of Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this research is to understand whether the drug metformin could be used in the future to help prevent patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) from developing multiple myeloma. The names of the study drug involved in this study is: * Metformin, extended release * Placebo ( a pill that has no active ingredients)
Who can join: Review the eligibility criteria below.
Location: Brigham and Women's Hospital — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (7 Sites)
- Brigham and Women's Hospital — Boston, Massachusetts
- Dana Farber Cancer Institute — Boston, Massachusetts
- Dana-Farber at Brighton — Brighton, Massachusetts
- Dana-Farber at Merrimack Valley — Methuen, Massachusetts
- Dana-Farber at Milford — Milford, Massachusetts
- DF/ BWCC in Clinical Affiliation with South Shore Hospital — Weymouth, Massachusetts
- Dana-Farber at NHOH — Londonderry, New Hampshire
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Monoclonal Gammopathy of Undetermined Significance
- A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) — Basking Ridge, New Jersey
- A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) — Atlanta, Georgia
- Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies — Houston, Texas
- Observational Prospective Research Study In Monoclonal Gammopathies leadINg to Myeloma — Houston, Texas
Explore by condition: All Monoclonal Gammopathy of Undetermined Significance clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.