๐๏ธ Verified NIH Record โข Updated 2026-06-18
A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors (NCT04857372)
An Open-label, Multi-center, Phase I Study of Oral IAG933 in Adult Patients With Advanced Mesothelioma and Other Solid Tumors
๐ต Active, Not Recruiting Phase1 ๐ Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this study is to characterize the safety and tolerability of IAG933 in patients with mesothelioma, NF2/LATS1/LATS2 mutated tumors and tumors with functional YAP/TAZ fusions and to identify the maximum tolerated dose and/or recommended dose.
Who can join: Review the eligibility criteria below.
Location: University of California LA โ Los Angeles, California
Age range: 18 Years to 120 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (16 Sites)
- University of California LA โ Los Angeles, California
- Uni of Chi Medi Ctr Hema and Onco โ Chicago, Illinois
- Massachusetts General Hospital โ Boston, Massachusetts
- Cleveland Clinic Foundation โ Cleveland, Ohio
- MD Anderson Cancer Center โ Houston, Texas
- Novartis Investigative Site โ Melbourne, Victoria
- Novartis Investigative Site โ Montreal, Quebec
- Novartis Investigative Site โ Villejuif,
- Novartis Investigative Site โ Essen,
- Novartis Investigative Site โ Milan, MI
- Novartis Investigative Site โ Rozzano, MI
- Novartis Investigative Site โ Chuo Ku, Tokyo
- Novartis Investigative Site โ Rotterdam, South Holland
- Novartis Investigative Site โ Barcelona,
- Novartis Investigative Site โ Zurich,
- Novartis Investigative Site โ Manchester,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Mesothelioma
- Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma โ Baltimore, Maryland
- Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma โ Tampa, Florida
- Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer โ San Francisco, California
- Olaparib in Patients With HRD Malignant Mesothelioma โ Chicago, Illinois
- A Study of Sacituzumab Govitecan in People With Mesothelioma โ Basking Ridge, New Jersey
Explore by condition: All Mesothelioma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.