🏛️ Verified NIH Record • Updated 2026-06-17

Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038)

🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: University Health Network, Toronto

🩺 Plain-English Summary (8th-Grade Level)

Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast cancer surgery.

Who can join: Review the eligibility criteria below.

Location: Foothills Medical Centre — Calgary, Alberta

Age range: 18 Years to 100 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (17 Sites)

  • Foothills Medical Centre — Calgary, Alberta
  • Sturgeon Community Hospital — Edmonton, Alberta
  • Eastern Health- Health Sciences Centre — St. John's, Newfoundland and Labrador
  • IWK — Halifax, Nova Scotia
  • Juravinski Hospital — Hamilton, Ontario
  • North York General Hospital — North York, Ontario
  • The Ottawa Hospital — Ottawa, Ontario
  • Thunder Bay Regional Health Sciences Centre — Thunder Bay, Ontario
  • Humber River Hospital — Toronto, Ontario
  • Mount Sinai Hospital — Toronto, Ontario
  • St. Michael's Hospital — Toronto, Ontario
  • Sunnybrook Health Sciences Centre — Toronto, Ontario
  • University Health Network — Toronto, Ontario
  • Women's College Hospital — Toronto, Ontario
  • Hôpital Maisonneuve-Rosemont — Montreal, Quebec
  • B.P. Koirala Institute of Health Sciences — Dharān,
  • Obafemi Awolowo University Teaching Hospitals Complex — Ile-Ife,

📞 Contact the Study Coordinator

Phone: (416) 340-4800

Email: James.Khan@medportal.ca

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Post-mastectomy Pain Syndrome clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗