Who is eligible for clinical trial NCT04877691?

Participants must meet protocol criteria for Systemic Lupus Erythematosus. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04877691 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-07-24

Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus (NCT04877691)

A Multicentre, Randomised, Double-Blind, Placebo-controlled, Phase 3 Study Evaluating the Efficacy and Safety of Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is evaluating the efficacy and safety of SC antifrolumab in adult patients with moderate -to-severe SLE despite receiving standard therapy

Who can join: Review the eligibility criteria below.

Location: Research Site — Birmingham, Alabama

Age range: 18 Years to 70 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (140 Sites)

Showing the first 25 of 140 sites.

Research Site — Birmingham, Alabama
Research Site — Paradise Valley, Arizona
Research Site — Phoenix, Arizona
Research Site — El Cajon, California
Research Site — Fullerton, California
Research Site — Hemet, California
Research Site — La Mesa, California
Research Site — Los Angeles, California
Research Site — Menifee, California
Research Site — Upland, California
Research Site — Aurora, Colorado
Research Site — Brandon, Florida
Research Site — Clearwater, Florida
Research Site — Clearwater, Florida
Research Site — Miami, Florida
Research Site — Tampa, Florida
Research Site — Tampa, Florida
Research Site — Idaho Falls, Idaho
Research Site — Flint, Michigan
Research Site — Lansing, Michigan
Research Site — Newark, New Jersey
Research Site — Las Cruces, New Mexico
Research Site — Brooklyn, New York
Research Site — Manhasset, New York
Research Site — New York, New York

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Systemic Lupus Erythematosus

A Study of Obexelimab in Patients With Systemic Lupus Erythematosus — Peoria, Arizona
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus — Anniston, Alabama
REACH (Restore Energy, Activity Can Help) Lupus Study — Boston, Massachusetts
A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice — Innsbruck, Tyrol
A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) — Birmingham, Alabama

Explore by condition: All Systemic Lupus Erythematosus clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗