The GUARDIAN Trial (NCT04884802)
Tight Perioperative Blood Pressure Management to Reduce Serious Cardiovascular, Renal, and Cognitive Complications: The GUARDIAN Trial
🩺 Plain-English Summary (8th-Grade Level)
An international randomized trial to test the primary hypothesis that perioperative tight blood pressure management reduces a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis, and death) in the 30 days after major non-cardiac surgery. The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Who can join: Review the eligibility criteria below.
Location: University of Nebraska Medical Center — Omaha, Nebraska
Age range: 45 Years
🧪 Interventions in This Study
- Tight blood pressure management (PROCEDURE)
- Routine blood pressure management (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- University of Nebraska Medical Center — Omaha, Nebraska
- Wake Forest University — Wake Forest, North Carolina
- MetroHealth Medical Center — Cleveland, Ohio
- Cleveland Clinic Fairview Hospital — Cleveland, Ohio
- Cleveland Clinic Main Campus — Cleveland, Ohio
- The University of Texas Health Science Center at Houston — Houston, Texas
- Beijing Shijitan Hospital, Capital Medical University — Beijing,
- Peking Union Medical College Hospital — Beijing,
- Peking University First Hospital — Beijing,
- West China University Hospital — Chengdu,
- Prince of Wales Hospital, Chinese University of Hong Kong, Shatin — Hong Kong,
- Renji Hospital, Shanghai Jiaotong University School of Medicine — Shanghai,
- Shanghai Chest Hospital — Shanghai,
- Shanghai Ninth People's Hospital — Shanghai,
- The Affiliated Lianyungang Hospital of Xuzhou Medical University — Xuzhou,
- University of Thessaly — Larissa,
- IRCCS Regina Elena National Cancer Institute — Rome,
- National Defense Medical College — Tokyo,
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital — Bakırköy,
- Konya City Hospital — Konya,
📞 Contact the Study Coordinator
Phone: (713) 500-4383
Email: Valerie.L.Anderson@uth.tmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.