๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-17

ATEMPT 2.0: Adjuvant T-DM1 vs TH (NCT04893109)

A Randomized Phase II Trial of Adjuvant Trastuzumab Emtansine (T-DM1) Followed by Subcutaneous Trastuzumab Versus Paclitaxel in Combination With Subcutaneous Trastuzumab for Stage I HER2-positive Breast Cancer (ATEMPT 2.0)

๐ŸŸข Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Dana-Farber Cancer Institute

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This research study is studying how well newly diagnosed breast cancer that has tested positive for a protein called HER2 responds using one of two different combination of HER2-directed therapies as a treatment after surgery. The name of the study drugs involved are: * Trastuzumab-emtansine (T-DM1, Kadcyla) * Trastuzumab SC (Herceptin Hylecta) * Paclitaxel

Who can join: Review the eligibility criteria below.

Location: UCSF Helen Diller Family Comprehensive Cancer Center โ€” San Francisco, California

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (53 Sites)

Showing the first 25 of 53 sites.

  • UCSF Helen Diller Family Comprehensive Cancer Center โ€” San Francisco, California
  • Smilow Cancer Hospital Care center at Derby โ€” Derby, Connecticut
  • Smilow Cancer Hospital Care center at Fairfield โ€” Fairfield, Connecticut
  • Smilow Cancer Hospital Care center at Glastonbury โ€” Glastonbury, Connecticut
  • Smilow Cancer Hospital Care center at Greenwich โ€” Greenwich, Connecticut
  • Smilow Cancer Hospital Care center at Guilford โ€” Guilford, Connecticut
  • Smilow Cancer Hospital Care center at St. Francis โ€” Hartford, Connecticut
  • Smilow Cancer Hospital Care center at Long Ridge โ€” Long Ridge, Connecticut
  • Yale Cancer Center at Yale University School of Medicine โ€” New Haven, Connecticut
  • Smilow Cancer Hospital Care center at North Haven โ€” North Haven, Connecticut
  • Stamford Hospital โ€” Stamford, Connecticut
  • Smilow Cancer Hospital Care center at Torrington โ€” Torrington, Connecticut
  • Smilow Cancer Hospital Care center at Trumbull โ€” Trumbull, Connecticut
  • Smilow Cancer Hospital Care center at Waterbury โ€” Waterbury, Connecticut
  • Smilow Cancer Hospital Care center at Waterford โ€” Waterford, Connecticut
  • Miami Cancer Institute/Baptist Hospital of Miami โ€” Miami, Florida
  • Miami Cancer Institute - Plantation (MCIP) โ€” Plantation, Florida
  • The University of Chicago Medical Center โ€” Chicago, Illinois
  • Indiana University Health Joe & Shelly Schwarz Cancer Center โ€” Carmel, Indiana
  • IU Health North Hospital โ€” Carmel, Indiana
  • Indiana University Melvin and Bren Simon Comprehensive Cancer Center โ€” Indianapolis, Indiana
  • Indiana University Sidney and Lois Eskenazi Hospital โ€” Indianapolis, Indiana
  • Eastern Maine Medical Center (Northern Light) โ€” Brewer, Maine
  • New England Cancer Specialists โ€” Scarborough, Maine
  • Beth Israel Deaconess Medical Center โ€” Boston, Massachusetts

๐Ÿ“ž Contact the Study Coordinator

Phone: (617) 632-2335

Email: sara_tolaney@dfci.harvard.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Breast Cancer clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—