๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-03-16

HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide (NCT04904588)

A Multi-Center, Phase II Trial of HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide for Patients With Hematologic Malignancies

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Center for International Blood and Marrow Transplant Research

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be used for for graft versus host disease (GVHD) prophylaxis. This trial will study how well this treatment works in patients with hematologic malignancies.

Who can join: Review the eligibility criteria below.

Location: City of Hope National Medical Center โ€” Duarte, California

Age range: 1 Year

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (39 Sites)

Showing the first 25 of 39 sites.

  • City of Hope National Medical Center โ€” Duarte, California
  • University of California San Francisco โ€” San Francisco, California
  • Stanford University โ€” Stanford, California
  • Colorado Blood Cancer Institute โ€” Denver, Colorado
  • University of Florida Health Shands Hospital โ€” Gainesville, Florida
  • University of Miami Sylvester Cancer Center โ€” Miami, Florida
  • H. Lee Moffitt Cancer Center and Research Institute โ€” Tampa, Florida
  • Children's Healthcare of Atlanta โ€” Atlanta, Georgia
  • Emory University Medical Center โ€” Atlanta, Georgia
  • Northwestern University โ€” Chicago, Illinois
  • The University of Chicago โ€” Chicago, Illinois
  • University of Maryland Medical Center โ€” Baltimore, Maryland
  • The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins โ€” Baltimore, Maryland
  • Tufts Medical Center โ€” Boston, Massachusetts
  • Dana Farber Cancer Institute โ€” Boston, Massachusetts
  • University of Michigan Medical Center - Mott Children's Hospita โ€” Ann Arbor, Michigan
  • Karmanos Cancer Institute โ€” Detroit, Michigan
  • Mayo Clinic Rochester โ€” Rochester, Minnesota
  • Washington University/Barnes Jewish Hospital โ€” St Louis, Missouri
  • Roswell Park Comprehensive Cancer Center โ€” Buffalo, New York
  • Columbia University Medical Center โ€” New York, New York
  • Memorial Sloan Kettering Cancer Center โ€” New York, New York
  • University of North Carolina Chapel Hill โ€” Chapel Hill, North Carolina
  • Cincinnati Children's Hospital โ€” Cincinnati, Ohio
  • Ohio State Medical Center, James Cancer Center โ€” Columbus, Ohio

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—