Initial Correction Keratoconus (NCT04918316)
Initial Correction Keratoconus: Scleral vs Corneal Gas Permeable Lenses SCOPE Study
🩺 Plain-English Summary (8th-Grade Level)
Keratoconus is a non-inflammatory, progressive disease in which corneal irregularity increases. As the condition develops, more advanced forms of optical correction are needed to improve vision for patients. Until recently, small diameter corneal gas permeable lenses were considered the primary mode of correction for patients with keratoconus. Now, however, practitioners have multiple options for reducing the optical aberrations caused by keratoconus, including scleral lenses. As of yet, no single option for optical correction has been identified as the preferred mode of correction in terms of overall patient satisfaction with vision, comfort, and ease of use. The order in which various forms of optical correction would be most logically introduced has yet to be determined. This is a study comparing small diameter corneal gas permeable and large diameter scleral lenses in individuals with keratoconus. This study will prospectively compare visual satisfaction and ease of use between corneal gas permeable and scleral lenses for patients with mild to moderate keratoconus.
Who can join: Review the eligibility criteria below.
Location: University of Illinois at Chicago Eye and Ear Infirmary — Chicago, Illinois
Age range: 18 Years
🧪 Interventions in This Study
- Corneal gas permeable lens (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- University of Illinois at Chicago Eye and Ear Infirmary — Chicago, Illinois
- Illinois Eye Institute — Chicago, Illinois
- Mayo Clinic — Rochester, Minnesota
- The Ohio State University College of Optometry — Columbus, Ohio
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Keratoconus
- McNeel Eye Center Corneal Crosslinking Study — Boise, Idaho
- Assessing Patient Engagement in Keratoconus Clinical Research — San Francisco, California
- Outcomes of CTAK Surgery — Palo Alto, California
- A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients — Boston, Massachusetts
- OCT in Diagnosis of Irregular Corneas — Portland, Oregon
Explore by condition: All Keratoconus clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.