Who is eligible for clinical trial NCT04924608?

Participants must meet protocol criteria for Neurofibromatosis 1. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04924608 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-03-19

Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas (NCT04924608)

A Phase III, Multicentre, International Study With a Parallel, Randomised, Double-blind, Placebo-controlled, 2 Arm Design to Assess the Efficacy and Safety of Selumetinib in Adult Participants With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas (KOMET)

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

A global study to demonstrate the effectiveness of selumetinib in participants with NF1 who have symptomatic, inoperable plexiform neurofibromas.

Who can join: Review the eligibility criteria below.

Location: Research Site — Gainesville, Florida

Age range: 18 Years

🧪 Interventions in This Study

Selumetinib (DRUG)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (34 Sites)

Showing the first 25 of 34 sites.

Research Site — Gainesville, Florida
Research Site — Rockville, Maryland
Research Site — St Louis, Missouri
Research Site — Commack, New York
Research Site — Melbourne,
Research Site — St Leonards,
Research Site — Porto Alegre,
Research Site — Ribeirão Preto,
Research Site — São Paulo,
Research Site — Toronto, Ontario
Research Site — Montreal, Quebec
Research Site — Beijing,
Research Site — Beijing,
Research Site — Guangzhou,
Research Site — Shenyang,
Research Site — Créteil,
Research Site — Lyon,
Research Site — Toulouse,
Research Site — Hamburg,
Research Site — Tübingen,
Research Site — Würzburg,
Research Site — Milan,
Research Site — Naples,
Research Site — Roma,
Research Site — Minatoku,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗