🏛️ Verified NIH Record • Updated 2025-10-08
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer (NCT04931654)
A Phase I/IIa Open-label Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD7789, an Anti-PD-1 and Anti-TIM-3 Bispecific Antibody, in Participants With Advanced or Metastatic Solid Tumors.
🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: AstraZeneca
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase I/IIa study designed to evaluate if experimental anti-PD-1 and anti-TIM-3 bispecific antibody, AZD7789 is safe, tolerable and efficacious in participants with advanced solid tumors.
Who can join: Review the eligibility criteria below.
Location: Research Site — Atlanta, Georgia
Age range: 18 Years to 130 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (21 Sites)
- Research Site — Atlanta, Georgia
- Research Site — Fort Wayne, Indiana
- Research Site — New York, New York
- Research Site — Nashville, Tennessee
- Research Site — Toronto, Ontario
- Research Site — Beijing,
- Research Site — Guangzhou,
- Research Site — Bordeaux,
- Research Site — Rennes,
- Research Site — Villejuif,
- Research Site — Tbilisi,
- Research Site — Chūōku,
- Research Site — Kashiwa,
- Research Site — Chisinau,
- Research Site — Amsterdam,
- Research Site — Barcelona,
- Research Site — Madrid,
- Research Site — Ankara,
- Research Site — Ankara,
- Research Site — Ankara,
- Research Site — Cordaleo,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.