๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-29

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients (NCT04939090)

A Randomized Phase III Trial of Olanzapine Versus Megestrol Acetate for Cancer-Associated Anorexia

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Alliance for Clinical Trials in Oncology

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This phase III trial compares the effects of olanzapine versus megestrol acetate in treating loss of appetite in patients with cancer that has spread to other places in the body (advanced). Olanzapine may stimulate and increase appetite. This study aims to find out if olanzapine is better than the usual approach (megestrol acetate) for stimulating appetite and preventing weight loss.

Who can join: Review the eligibility criteria below.

Location: Arizona Center for Cancer Care - Gilbert โ€” Gilbert, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (293 Sites)

Showing the first 25 of 293 sites.

  • Arizona Center for Cancer Care - Gilbert โ€” Gilbert, Arizona
  • CTCA at Western Regional Medical Center โ€” Goodyear, Arizona
  • Arizona Center for Cancer Care-Peoria โ€” Peoria, Arizona
  • Arizona Center for Cancer Care - Phoenix โ€” Phoenix, Arizona
  • Arizona Center for Cancer Care - Osborn โ€” Scottsdale, Arizona
  • Arizona Center for Cancer Care - Scottsdale โ€” Scottsdale, Arizona
  • Arizona Center for Cancer Care-Surprise โ€” Surprise, Arizona
  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro โ€” Jonesboro, Arkansas
  • Epic Care-Dublin โ€” Dublin, California
  • Epic Care Partners in Cancer Care โ€” Emeryville, California
  • Washington Hospital โ€” Fremont, California
  • Contra Costa Regional Medical Center โ€” Martinez, California
  • Bay Area Tumor Institute โ€” Oakland, California
  • Zuckerberg San Francisco General Hospital โ€” San Francisco, California
  • Dominican Santa Cruz Hospital โ€” Santa Cruz, California
  • Epic Care Cyberknife Center โ€” Walnut Creek, California
  • Rocky Mountain Cancer Centers-Aurora โ€” Aurora, Colorado
  • Rocky Mountain Cancer Centers-Boulder โ€” Boulder, Colorado
  • Rocky Mountain Cancer Centers - Centennial โ€” Centennial, Colorado
  • Rocky Mountain Cancer Centers-Midtown โ€” Denver, Colorado
  • Rocky Mountain Cancer Centers-Rose โ€” Denver, Colorado
  • Mountain Blue Cancer Care Center - Swedish โ€” Englewood, Colorado
  • Rocky Mountain Cancer Centers - Swedish โ€” Englewood, Colorado
  • Grand Valley Oncology โ€” Grand Junction, Colorado
  • Rocky Mountain Cancer Centers-Lakewood โ€” Lakewood, Colorado

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—