Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA (NCT04942210)
Controlled Study of Immunogenicity and Safety of the Investigational vYF Candidate Vaccine in Comparison to YF-VAX in Adults
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of the study is to demonstrate the non-inferiority of the antibody response in terms of seroconversion rate 28 days after vaccine administration of one dose of yellow fever vaccine (vYF) compared to the antibody response after one dose of the YF-VAX control vaccine in yellow fever naïve participants. The secondary objectives of the study are: * To describe the immune response to yellow fever in both vaccine groups before and after vYF or YF-VAX administration. * To describe the safety profile of vYF vaccine in comparison to the safety profile of the control YF-VAX. * To describe the biosafety profile of vYF in comparison to the biosafety profile of the control YF-VAX.
Who can join: Review the eligibility criteria below.
Location: Emory University Decatur- Site Number : 8400005 — Decatur, Georgia
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- Emory University Decatur- Site Number : 8400005 — Decatur, Georgia
- Velocity Clinical Research- New Orleans Site Number : 8400008 — New Orleans, Louisiana
- Johns Hopkins Bloomberg School of Public Health (JHSPH)- Site Number : 8400004 — Baltimore, Maryland
- Harvard University Medical School- Site Number : 8400002 — Boston, Massachusetts
- Saint Louis University- Site Number : 8400003 — St Louis, Missouri
- Meridian Clinical Research- Site Number : 8400009 — Omaha, Nebraska
- SUNY Upstate Medical University Global Health Institute Site Number : 8400006 — East Syracuse, New York
- New York University Langone Medical Center Site Number : 8400013 — New York, New York
- Rochester Clinical Research, Inc.- Site Number : 8400010 — Rochester, New York
- Velocity Clinical Research - Providence Site Number : 8400015 — East Greenwich, Rhode Island
- J Lewis Research Inc- Site Number : 8400012 — Salt Lake City, Utah
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.