๐๏ธ Verified NIH Record โข Updated 2026-05-22
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE) (NCT04951219)
A 52-Week, Phase 3, Open-Label Extension Study, With a Double-blind Lead-in, to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
๐ต Active, Not Recruiting Phase3 ๐ Investigational Drug / Biologic Sponsor: Madrigal Pharmaceuticals, Inc.
๐ฉบ Plain-English Summary (8th-Grade Level)
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Who can join: Review the eligibility criteria below.
Location: Central Research Associates โ Birmingham, Alabama
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (76 Sites)
Showing the first 25 of 76 sites.
- Central Research Associates โ Birmingham, Alabama
- Arizona Liver Health - Chandler โ Chandler, Arizona
- East Valley Family Physicians โ Chandler, Arizona
- The Institute For Liver Health - Glendale โ Glendale, Arizona
- The Institute For Liver Health - Tucson โ Tucson, Arizona
- Adobe Gastroenterology โ Tucson, Arizona
- Arkansas Gastroenterology โ North Little Rock, Arkansas
- Fresno Clinical Research Center โ Fresno, California
- National Research Institute - Huntington Park โ Huntington Park, California
- Ruane Clinical Research Group โ Los Angeles, California
- Cedars-Sinai Medical Center โ Los Angeles, California
- National Research Institute - Los Angeles โ Los Angeles, California
- National Research Institute - Panorama City โ Panorama City, California
- San Fernando Valley Health Institute โ West Hills, California
- South Denver Gastroenterology - Swedish Medical Center Office โ Englewood, Colorado
- Excel Medical Clinical Trials โ Boca Raton, Florida
- Covenant Research โ Fort Myers, Florida
- Velocity Clinical Research, Hallandale Beach (MD Clinical) โ Hallandale, Florida
- Floridian Clinical Research โ Hialeah, Florida
- Nature Coast Clinical Research - Inverness โ Inverness, Florida
- Jacksonville Center for Clinical Research โ Jacksonville, Florida
- Florida Research Institute โ Lakewood Rch, Florida
- Floridian Clinical Research โ Miami Lakes, Florida
- Orlando Research Center โ Orlando, Florida
- Progressive Medical Research โ Port Orange, Florida
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Non-Alcoholic Fatty Liver Disease
- Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis โ Chula Vista, California
- Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk โ St Louis, Missouri
- A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) โ Chandler, Arizona
- SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease โ Chicago, Illinois
- The Olmsted NAFLD Epidemiology Study (TONES) โ Rochester, Minnesota
Explore by condition: All Non-Alcoholic Fatty Liver Disease clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.