πŸ›οΈ Verified NIH Record β€’ Updated 2026-05-27

Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C) (NCT04956640)

A Phase 1/2 Study of LY3537982 in Patients With KRAS G12C-Mutant Advanced Solid Tumors

πŸ”΅ Active, Not Recruiting Phase1 / Phase2 πŸ’Š Investigational Drug / Biologic Sponsor: Eli Lilly and Company

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C). Patients must have already received or were not able to tolerate the standard of care, except for specific groups who have not had cancer treatment. The study will last up to approximately 4 years.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham β€” Birmingham, Alabama

Age range: 18 Years

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (49 Sites)

Showing the first 25 of 49 sites.

  • University of Alabama at Birmingham β€” Birmingham, Alabama
  • USC Norris Cancer Hospital β€” Los Angeles, California
  • Chao Family Comprehensive Cancer Ctr. β€” Orange, California
  • Yale-New Haven Hospital β€” New Haven, Connecticut
  • AdventHealth Orlando β€” Orlando, Florida
  • Florida Cancer Specialists β€” Sarasota, Florida
  • Indiana Univ Melvin & Bren Simon Cancer Center β€” Indianapolis, Indiana
  • Community Health Network β€” Indianapolis, Indiana
  • Mary Bird Perkins Cancer Center β€” Baton Rouge, Louisiana
  • Massachusetts General Hospital β€” Boston, Massachusetts
  • Dartmouth-Hitchcock Medical Center β€” Lebanon, New Hampshire
  • NYU Langone Health- Long Island β€” Mineola, New York
  • NYU Langone β€” New York, New York
  • Memorial Sloan Kettering Cancer Center β€” New York, New York
  • The University of North Carolina at Chapel Hill β€” Chapel Hill, North Carolina
  • Novant Health Cancer Institute - Elizabeth β€” Charlotte, North Carolina
  • Novant Health Cancer Institute - Forsyth β€” Winston-Salem, North Carolina
  • Fox Chase Cancer Center β€” Philadelphia, Pennsylvania
  • UPMC Hillman Cancer Center β€” Pittsburgh, Pennsylvania
  • Sarah Cannon Cancer Center β€” Nashville, Tennessee
  • Vanderbilt Univeristy School of Medicine β€” Nashville, Tennessee
  • South Texas Accelerated Research Therapeutics (START) β€” San Antonio, Texas
  • START Mountain Region β€” West Valley City, Utah
  • Inova Health System IRB β€” Fairfax, Virginia
  • USO-Virginia Cancer Specialists, PC β€” Fairfax, Virginia

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—