A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma (NCT04973605)
A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone, Dexamethasone/Carfilzomib, Dexamethasone/Daratumumab, and Dexamethasone/Pomalidomide in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)
π©Ί Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with relapsed/refractory (R/R) multiple myeloma (MM) and chromosomal translocation t(11;14). The study investigates sonrotoclax alone and in combination with dexamethasone and other agents, including carfilzomib, daratumumab, and pomalidomide.
Who can join: Review the eligibility criteria below.
Location: University of Alabama At Birmingham Hospital β Birmingham, Alabama
Age range: 18 Years
π§ͺ Interventions in This Study
π "Do I Qualify?" β 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria β
π All Participating Trial Locations (82 Sites)
Showing the first 25 of 82 sites.
- University of Alabama At Birmingham Hospital β Birmingham, Alabama
- City of Hope National Medical Center β Duarte, California
- City of Hope Irvine Lennar β Irvine, California
- University of Miami β Miami, Florida
- Emory University Winship Cancer Center β Atlanta, Georgia
- University of Chicago Medical Center β Chicago, Illinois
- Massachusetts General Hospital β Boston, Massachusetts
- Washington University School of Medicine β St Louis, Missouri
- Hackensack University Medical Center β Hackensack, New Jersey
- Weill Cornell Medical College Newyork Presbyterian Hospital β New York, New York
- Memorial Sloan Kettering Cancer Center Mskcc β New York, New York
- The James Cancer Hospital and Solove Research Institute At Ohio State University β Columbus, Ohio
- Huntsman Cancer Institute β Salt Lake City, Utah
- University of Washington β Seattle, Washington
- University of Wisconsin Carbone Cancer Center β Madison, Wisconsin
- Medical College of Wisconsin β Milwaukee, Wisconsin
- Canberra Hospital β Garran, Australian Capital Territory
- Nepean Hospital β Kingswood, New South Wales
- Monash Health β Clayton, Victoria
- St Vincents Hospital Melbourne β Fitzroy, Victoria
- The Alfred Hospital β Melbourne, Victoria
- Royal Perth Hospital β Perth, Western Australia
- Hospital Sirio Libanes Brasilia β BrasΓlia,
- Instituto Dor de Pesquisa E Ensino Distrito Federal β BrasΓlia,
- Centro Gaucho Integrado de Oncologia Hospital Mae de Deus β Porto Alegre,
π Contact the Study Coordinator
Phone: (877) 828-5568
Email: clinicaltrials@beonemed.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
π° Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Relapsed/Refractory Multiple Myeloma
- A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets β Stanford, California
- A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma β Little Rock, Arkansas
- Cevostamab Following CAR T Cell Therapy for RRMM β Philadelphia, Pennsylvania
- A Collaborative Community Effort Using Belantamab Mafodotin in Relapsed/Refractory Myeloma β Clayton, North Carolina
- CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma β Birmingham, Alabama
Explore by condition: All Relapsed/Refractory Multiple Myeloma clinical trials
π‘ How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.