πŸ›οΈ Verified NIH Record β€’ Updated 2026-08-21

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma (NCT04973605)

A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone, Dexamethasone/Carfilzomib, Dexamethasone/Daratumumab, and Dexamethasone/Pomalidomide in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)

🟒 Recruiting Phase1 / Phase2 πŸ’Š Investigational Drug / Biologic Sponsor: BeOne Medicines

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with relapsed/refractory (R/R) multiple myeloma (MM) and chromosomal translocation t(11;14). The study investigates sonrotoclax alone and in combination with dexamethasone and other agents, including carfilzomib, daratumumab, and pomalidomide.

Who can join: Review the eligibility criteria below.

Location: University of Alabama At Birmingham Hospital β€” Birmingham, Alabama

Age range: 18 Years

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (82 Sites)

Showing the first 25 of 82 sites.

  • University of Alabama At Birmingham Hospital β€” Birmingham, Alabama
  • City of Hope National Medical Center β€” Duarte, California
  • City of Hope Irvine Lennar β€” Irvine, California
  • University of Miami β€” Miami, Florida
  • Emory University Winship Cancer Center β€” Atlanta, Georgia
  • University of Chicago Medical Center β€” Chicago, Illinois
  • Massachusetts General Hospital β€” Boston, Massachusetts
  • Washington University School of Medicine β€” St Louis, Missouri
  • Hackensack University Medical Center β€” Hackensack, New Jersey
  • Weill Cornell Medical College Newyork Presbyterian Hospital β€” New York, New York
  • Memorial Sloan Kettering Cancer Center Mskcc β€” New York, New York
  • The James Cancer Hospital and Solove Research Institute At Ohio State University β€” Columbus, Ohio
  • Huntsman Cancer Institute β€” Salt Lake City, Utah
  • University of Washington β€” Seattle, Washington
  • University of Wisconsin Carbone Cancer Center β€” Madison, Wisconsin
  • Medical College of Wisconsin β€” Milwaukee, Wisconsin
  • Canberra Hospital β€” Garran, Australian Capital Territory
  • Nepean Hospital β€” Kingswood, New South Wales
  • Monash Health β€” Clayton, Victoria
  • St Vincents Hospital Melbourne β€” Fitzroy, Victoria
  • The Alfred Hospital β€” Melbourne, Victoria
  • Royal Perth Hospital β€” Perth, Western Australia
  • Hospital Sirio Libanes Brasilia β€” BrasΓ­lia,
  • Instituto Dor de Pesquisa E Ensino Distrito Federal β€” BrasΓ­lia,
  • Centro Gaucho Integrado de Oncologia Hospital Mae de Deus β€” Porto Alegre,

πŸ“ž Contact the Study Coordinator

Phone: (877) 828-5568

Email: clinicaltrials@beonemed.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—