Imaging CRF X NOP Interactions in CUD (NCT05008146)
Imaging Corticotrophin-releasing Factor (CRF) X Nociceptive Opioid Peptide (NOP) Interactions in Cocaine Use Disorders (Aim 1)
🩺 Plain-English Summary (8th-Grade Level)
This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.
Who can join: Review the eligibility criteria below.
Location: University of Pittsburgh — Pittsburgh, Pennsylvania
Age range: 18 Years to 55 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Pittsburgh — Pittsburgh, Pennsylvania
📞 Contact the Study Coordinator
Phone: (412) 647-5176
Email: narendranr@upmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cocaine Use Disorder
- Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study — New Haven, Connecticut
- Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study — Pittsburgh, Pennsylvania
- Cocaine Cue-reactivity Incubation Study — New York, New York
- Repurposing Semaglutide for the Treatment of Cocaine Use Disorder — Houston, Texas
- Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder — New York, New York
- Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder — Houston, Texas
Explore by condition: All Cocaine Use Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.