COAST Therapy in Advanced Solid Tumors and Prostate Cancer (NCT05036226)
Combination of Autophagy Selective Therapeutics (COAST) in Advanced Solid Tumors or Relapsed Prostate Cancer, A Phase I/II Trial
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine, metformin, sirolimus, dasatinib and nelfinavir and are given orally.
Who can join: Review the eligibility criteria below.
Location: Medical University of South Carolina — Charleston, South Carolina
Age range: 18 Years
🧪 Interventions in This Study
- Hydroxychloroquine, Metformin, Sirolimus (COMBINATION_PRODUCT)
- Hydroxychloroquine, Metformin, Sirolimus, Dasatanib (COMBINATION_PRODUCT)
- Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir (COMBINATION_PRODUCT)
- Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib (COMBINATION_PRODUCT)
- Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir (COMBINATION_PRODUCT)
- Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib (COMBINATION_PRODUCT)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Medical University of South Carolina — Charleston, South Carolina
📞 Contact the Study Coordinator
Phone: (843) 792-9321
Email: hcc-clinical-trials@musc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.