Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain (NCT05037123)
🩺 Plain-English Summary (8th-Grade Level)
The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35 mg/kg dose after induction, followed by a 0.25 mg/kg/hr infusion during surgery (up to a maximum of 6 hours) and continued for 2 hours postoperatively. Participants in the second arm will receive a single dose of 0.6 mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the control group and receive saline (no ketamine).
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (14 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- University of Arkansas — Little Rock, Arkansas
- Rush University Medical Center — Chicago, Illinois
- Brigham and Women's Hospital - Harvard University — Chestnut Hill, Massachusetts
- Mayo Clinic — Rochester, Minnesota
- Washington University at St. Louis Medical Center — St Louis, Missouri
- NYU Langone Health (Tisch Hospital, Kimmel Pavilion) — New York, New York
- New York Presbyterian Columbia University Irving Medical Center — New York, New York
- Memorial Sloan Kettering Cancer Center — New York, New York
- Montefiore Medical Center - Albert Einstein College of Medicine — The Bronx, New York
- University of Pittsburgh - Magee Women's Hospital — Pittsburgh, Pennsylvania
- University of Texas - Southwestern Medical Center — Dallas, Texas
- University of Texas - MD Anderson Cancer Center — Houston, Texas
- University of Washington Medical Center — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Chronic Postsurgical Pain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.