๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-10

Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms Trial (NCT05039424)

A Randomized, Sham-controlled Trial: Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms (EMPTIES)

๐Ÿ”ต Active, Not Recruiting Observational / Diagnostic ๐Ÿฉบ Clinical Procedure Protocol Sponsor: Matthew Allemang

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

A randomized clinical trial comparing endoscopic per-oral pyloromyotomy (POP) versus a control sham intervention (diagnostic esophagogastroduodenoscopy (EGD) without pyloric disruption) in patients with medically refractory gastroparesis.

Who can join: Review the eligibility criteria below.

Location: Cleveland Clinic Foundation โ€” Cleveland, Ohio

Age range: 18 Years to 75 Years

๐Ÿงช Interventions in This Study

  • Endoscopic per-oral pyloromyotomy (POP) (PROCEDURE)
  • Diagnostic esophagogastroduodenoscopy (EGD) without pyloric disruption (PROCEDURE)

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (1 Sites)

  • Cleveland Clinic Foundation โ€” Cleveland, Ohio

๐Ÿ“ž Contact the Study Coordinator

Phone: (866) 223-8100

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Gastroparesis clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—