RAPid SimPLE Targeted Radiation Treatment for Brain Metastases (NCT05050929)
Randomized Phase II Non-Inferiority Study of 5-Day Versus 1-Day RAPid SimPLE (RAPPLE) Targeted Radiation Treatment for Brain Metastases
🩺 Plain-English Summary (8th-Grade Level)
The aim of the study is to show that rapid, simple targeted radiotherapy to brain metastases with 8 Gy / 1 is non-inferior to 20 Gy / 5 in terms of overall survival for patients with poor prognosis.
Who can join: Review the eligibility criteria below.
Location: BC Cancer - Abbotsford — Abbotsford British Columbia, British Columbia
Age range: 18 Years to 100 Years
🧪 Interventions in This Study
- Targeting All Brain Metastases (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (6 Sites)
- BC Cancer - Abbotsford — Abbotsford British Columbia, British Columbia
- BC Cancer - Kelowna — Kelowna, British Columbia
- BC Cancer - Prince George — Prince George, British Columbia
- BC Cancer - Surrey — Surrey, British Columbia
- BC Cancer - Vancouver — Vancouver, British Columbia
- BC Cancer - Victoria — Victoria, British Columbia
📞 Contact the Study Coordinator
Phone: (604) 877-6000
Email: sandy.chang@bccancer.bc.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Brain Metastases, Adult
- A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases — Pittsburgh, Pennsylvania
- Brain Imaging Biomarkers in Patients With Brain Metastasis — Toronto, Ontario
- Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction — Boston, Massachusetts
- Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial — Burlington, Vermont
- Multi-disciplinary Care for Brain Metastases — Burlington, Vermont
- Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery — Miami, Florida
Explore by condition: All Brain Metastases, Adult clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.