A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis (NCT05070858)
Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Monotherapy in Patients With Symptomatic Generalized Myasthenia Gravis
🩺 Plain-English Summary (8th-Grade Level)
This study is researching the experimental drugs called pozelimab and cemdisiran, and cemdisiran monotherapy. The study is focused on patients with generalized Myasthenia Gravis (gMG). Myasthenia gravis is a disease that causes weakness and fatigue in muscles in the body because the nerves and muscles are not communicating properly. The aim of the study is to see how effective pozelimab and cemdisiran are when used in combination and when pozelimab and cemdisiran are used alone for patients with gMG. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs * How the study drugs work inside the body * How much of the study drugs are in the blood at different times * Whether the body makes antibodies against pozelimab and cemdisiran (which could make the drugs less effective or could lead to side effects)
Who can join: Review the eligibility criteria below.
Location: HonorHealth Neurology 2018 — Scottsdale, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (116 Sites)
Showing the first 25 of 116 sites.
- HonorHealth Neurology 2018 — Scottsdale, Arizona
- University of California Irvine — Irvine, California
- University of Southern California — Los Angeles, California
- Colorado Springs Neurological Associates — Colorado Springs, Colorado
- SFM Clinical Research, LLC — Boca Raton, Florida
- Diverse Clinical Research — Miami, Florida
- Aqualane Clinical Research — Naples, Florida
- Neurological Services of Orlando — Orlando, Florida
- Medsol Clinical Research Center Inc — Port Charlotte, Florida
- University of South Florida Morsani Center for Advanced Healthcare — Tampa, Florida
- NorthShore University Health System — Glenview, Illinois
- St. Elizabeth's Hospital — O'Fallon, Illinois
- Northwest Neurology Ltd. - Clinedge - PPDS — Rolling Meadows, Illinois
- Wayne State University School of Medicine — Detroit, Michigan
- Dayton Center for Neurological Disorders — Centerville, Ohio
- University of Cincinnati Gardner Neuroscience Institute — Cincinnati, Ohio
- Penn Medicine University City — Philadelphia, Pennsylvania
- National Neuromuscular Research Institute — Austin, Texas
- Nerve and Muscle Center of Texas — Houston, Texas
- Universitair Ziekenhuis Antwerpen — Edegem, Antwerp
- AZ Sint-Lucas — Ghent, Oost-Vlaanderen
- IMV Pesquisa Neurologica — Porto Alegre, Rio Grande do Sul
- Jordy Sinapse Medicina LTDA — Itapevi, São Paulo
- Faculdade de Medicina Do ABC — Santo André, São Paulo
- Pseg Centro de Pesquisa Clinica S.A — São Paulo,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Generalized Myasthenia Gravis
- A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis — Scottsdale, Arizona
- Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis — Orange, California
- Evaluation of PK, PD, Efficacy, Safety, and Immunogenicity of IV Ravulizumab in Pediatric Participants With Generalized Myasthenia Gravis — Los Angeles, California
- Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis — Phoenix, Arizona
- A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG. — Scottsdale, Arizona
Explore by condition: All Generalized Myasthenia Gravis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.