๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-27

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (NCT05083169)

A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to compare the efficacy of teclistamab daratumumab (Tec-Dara) with daratumumab subcutaneously (SC) in combination with pomalidomide and dexamethasone (DPd) or daratumumab SC in combination with bortezomib and dexamethasone (DVd).

Who can join: Review the eligibility criteria below.

Location: University of Alabama Birmingham โ€” Birmingham, Alabama

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (176 Sites)

Showing the first 25 of 176 sites.

  • University of Alabama Birmingham โ€” Birmingham, Alabama
  • City of Hope โ€” Duarte, California
  • Stanford University Medical Center โ€” Stanford, California
  • Yale University โ€” New Haven, Connecticut
  • Emory University Winship Cancer Institute โ€” Atlanta, Georgia
  • Tufts Medical Center โ€” Boston, Massachusetts
  • Henry Ford Hospital โ€” Detroit, Michigan
  • Henry Ford Health System โ€” Southfield, Michigan
  • Cleveland Clinic โ€” Cleveland, Ohio
  • West Penn Hospital โ€” Pittsburgh, Pennsylvania
  • University of Pittsburgh Medical Center โ€” Pittsburgh, Pennsylvania
  • Medical University of South Carolina โ€” Charleston, South Carolina
  • Baptist Cancer Center โ€” Memphis, Tennessee
  • Vanderbilt Ingram Cancer Center โ€” Nashville, Tennessee
  • University of Texas Southwestern Medical Center โ€” Dallas, Texas
  • Huntsman Cancer Institute โ€” Salt Lake City, Utah
  • Fred Hutchinson Cancer Center โ€” Seattle, Washington
  • University of Wisconsin Carbone Cancer Center โ€” Madison, Wisconsin
  • Hospital Italiano de Buenos Aires โ€” Buenos Aires,
  • Hospital Aleman โ€” CABA,
  • Hospital Privado Centro Medico de Cordoba โ€” Cรณrdoba,
  • ZAS Cadix โ€” Antwerp,
  • AZ St.-Jan Brugge-Oostende AV โ€” Bruges,
  • UZ Gent โ€” Ghent,
  • Hopital de Jolimont โ€” Haine Saint Paul La Louviere,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Multiple Myeloma clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—