🏛️ Verified NIH Record • Updated 2026-01-05

Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (NCT05114096)

Single Dose of Antenatal Corticosteroids (SNACS) Randomized Controlled Trial for Pregnancies at Risk of Preterm Delivery: To Keep Babies and Children Safe

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: McMaster University

🩺 Plain-English Summary (8th-Grade Level)

Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome. The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity. The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.

Who can join: Review the eligibility criteria below.

Location: University of Calgary, Cumming School of Medicine — Calgary, Alberta

Age range: 18 Years to 55 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (25 Sites)

  • University of Calgary, Cumming School of Medicine — Calgary, Alberta
  • Alberta Health Services; University of Alberta — Edmonton, Alberta
  • Royal Columbian Hospital — New Westminster, British Columbia
  • Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre — Surrey, British Columbia
  • University of British Columbia; BC Women's Hospital — Vancouver, British Columbia
  • Victoria General Hospital — Victoria, British Columbia
  • University of Manitoba, Health Sciences Centre — Winnipeg, Manitoba
  • University of Manitoba; St. Boniface General Hospital — Winnipeg, Manitoba
  • Dr. Everett Chalmers Regional Hospital — Fredericton, New Brunswick
  • The Moncton Hospital, Horizon Health Network — Moncton, New Brunswick
  • Memorial University, Eastern Health — St. John's, Newfoundland and Labrador
  • Dalhousie University; Izaak Walton Killam Health — Halifax, Nova Scotia
  • McMaster University — Hamilton, Ontario
  • Queen's University, Kingston General Hospital Health Sciences Centre — Kingston, Ontario
  • Western University; London Health Sciences Centre, Victoria Hospital — London, Ontario
  • University of Ottawa; The Ottawa Hospital — Ottawa, Ontario
  • Mount Sinai Hospital — Toronto, Ontario
  • Sunnybrook Health Sciences Center — Toronto, Ontario
  • Hopital Maisonneuve Rosemont, CIUSSS de l'est de l'Ile de Montréal — Montreal, Quebec
  • McGill University, McGill University Health Center, Royal Victoria Hospital — Montreal, Quebec
  • Sir Mortimer B. Davis Jewish General Hospital; McGill University — Montreal, Quebec
  • The Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal — Montreal, Quebec
  • Université Laval, Centre de recherche du CHU de Québec — Québec, Quebec
  • (CIUSSS de l'Estrie-CHUS); Université de Sherbrooke — Sherbrooke, Quebec
  • University of Saskatchewan, Regina General Hospital — Saskatoon, Saskatchewan

📞 Contact the Study Coordinator

Phone: (905) 525-9140

Email: mcdonals@mcmaster.ca

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Preterm Birth clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗