🏛️ Verified NIH Record • Updated 2026-07-01
Screening for High Frequency Malignant Disease (NCT05117840)
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Guardant Health, Inc.
🩺 Plain-English Summary (8th-Grade Level)
The SHIELD (Screening for High Frequency Malignant Disease) study is a prospective, observational, multi-site basket design trial without randomization. The primary objective of the study is to evaluate the sensitivity and specificity of a blood-based GuardantLUNAR-2 test to detect high frequency cancer in screen-relevant populations.
Who can join: Review the eligibility criteria below.
Location: University of Alabama Birmingham Lung Health Center — Birmingham, Alabama
Age range: 50 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (143 Sites)
Showing the first 25 of 143 sites.
- University of Alabama Birmingham Lung Health Center — Birmingham, Alabama
- Highlands Oncology Group PA — Fayetteville, Arkansas
- Pacific Cancer Medical Center — Anaheim, California
- Providence St. Joseph Hospital Eureka Cancer Program — Eureka, California
- SoCal Clinical Research — Fountain Valley, California
- Advanced Investigative Medicine — Hawthorne, California
- Cedars-Sinai Medical Center — Los Angeles, California
- California Medical Research Associates Inc. — Northridge, California
- Providence Medical Foundation — Santa Rosa, California
- Starling Physicians — New Britain, Connecticut
- George Washington University Medical Center — Washington D.C., District of Columbia
- Central Florida Pulmonary Group, P.A. — Altamonte Springs, Florida
- Pulmonary, Critical Care & Sleep Disorders Institute of South Florida — Atlantis, Florida
- CTMD Research — Coconut Creek, Florida
- Life Arc Research Centers — Coral Gables, Florida
- Pulmonary Physicians of South Florida, LLC — Coral Springs, Florida
- SIMED Health, LLC — Gainesville, Florida
- National Research Institute — Hialeah, Florida
- 3Sync Research — Hialeah, Florida
- Zenith Clinical Research — Hollywood, Florida
- Multi-Specialty Research Associates, Inc. — Lake City, Florida
- 3Sync Research — Lake Worth, Florida
- Adtremed INC — Lutz, Florida
- Las Mias Research and Medical Center — Miami, Florida
- Monzon Clinical Trials — Miami, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.