EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial) (NCT05151172)
A Multicentre, Prospective, Randomized, Parallel Group, Open-label Design to Determine the Efficacy and Safety of Endovascular Thrombectomy for Ischemic Stroke Patients With Symptomatic Acute Medium Vessel Intracranial Occlusions
🩺 Plain-English Summary (8th-Grade Level)
Stroke occurs when a blood clot causes a blockage in a blood vessel (artery) within the brain. This type of stroke is called an ischemic stroke and carries a high risk of disability or death. Stroke must be treated very fast. Any delay of even 10 minutes can result in the difference between an independent and a disabled outcome, and in some cases between life and death. Endovascular therapy (EVT) or Thrombectomy is a procedure to remove the blood clot (thrombus) from a blood vessel to reopen it (recanalization). Patients are likely to benefit from a thrombectomy procedure when it is performed in a larger blood vessel. Currently it is not known if thrombectomy procedure will benefit the patients presenting with the stroke that has been caused by a blood clot in a medium sized blood vessel (medium vessel occlusion, MeVO). This trial will enrol patients diagnosed with acute stroke due to a clot in the medium sized vessel. The patients will be randomized within 12 hours of their symptom onset to either standard of care or standard of care plus thrombectomy procedure. The participation will last for 12 months Escape MeVO coordinating centre is located at the University of Calgary. There will be up to 75 sites. We will be recruiting a total of 530 patients.
Who can join: Review the eligibility criteria below.
Location: Baptist Health Medical Center — Little Rock, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (53 Sites)
Showing the first 25 of 53 sites.
- Baptist Health Medical Center — Little Rock, Arkansas
- Sutter Health — San Francisco, California
- Providence Little company of Mary — Torrance, California
- Yale School of Medicine — New Haven, Connecticut
- Baptist Health Medical Centre — Jacksonville, Florida
- Mayo Clinic — Jacksonville, Florida
- Tampa General Hospital — Tampa, Florida
- Northwestern Medicine — Chicago, Illinois
- Rush university Medical Centre — Chicago, Illinois
- University of Kansas Medical Center — Kansas City, Kansas
- University of Maryland — Baltimore, Maryland
- bBston Medican Center — Boston, Massachusetts
- Mount Sinai Health System — New York, New York
- The Ohio State University — Columbus, Ohio
- Ohio Health (Columbus ORI) — Columbus, Ohio
- University of Toledo — Toledo, Ohio
- Thomas Jefferson University — Philadelphia, Pennsylvania
- University of TN Health Sciences Centre — Memphis, Tennessee
- Texas stroke Institute — Plano, Texas
- Swedish Medical Centre — Seattle, Washington
- University of Calgary - Foothills Medical Centre — Calgary, Alberta
- University of Alberta Hospital — Edmonton, Alberta
- Vancouver general hospital — Vancouver, British Columbia
- University of Manitoba — Winnipeg, Manitoba
- Queen Elizabeth II HSC — Halifax, Nova Scotia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Acute Ischemic Stroke
- PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke — Edmonton, Alberta
- An EFS to Evaluate the CGuard Prime™ Carotid Stent in Acute Ischemic Stroke — Buffalo, New York
- Safety Of A Second Dose Of Tenecteplase In Selected Acute Ischemic Stroke Patients Not Responding To The First Dose — Houston, Texas
- Efficacy and Safety of Xinglou Chengqi Granule for Acute Ischemic Stroke — Richmond, British Columbia
- Quelling of Excitotoxicity in Acute Stroke With Ketamine — Wynnewood, Pennsylvania
Explore by condition: All Acute Ischemic Stroke clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.