🏛️ Verified NIH Record • Updated 2026-08-14
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2) (NCT05156281)
A Randomized, Double-blind, Double-dummy, Parallel-group Study, Comparing the Efficacy and Safety of Remibrutinib Versus Teriflunomide in Participants With Relapsing Multiple Sclerosis, Followed by Extended Treatment With Open-label Remibrutinib
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals
🩺 Plain-English Summary (8th-Grade Level)
To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)
Who can join: Review the eligibility criteria below.
Location: Ctr for Neurology and Spine — Phoenix, Arizona
Age range: 18 Years to 55 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (223 Sites)
Showing the first 25 of 223 sites.
- Ctr for Neurology and Spine — Phoenix, Arizona
- Vladimir Royter MD APMC — Hanford, California
- VA Greater LA Healthcare System — Los Angeles, California
- Regina Berkovich MD PhD Inc — West Hollywood, California
- CU Anschutz Med Campus — Aurora, Colorado
- Colorado Neurological Research PC — Denver, Colorado
- New England Institute for Clinical Research — Stamford, Connecticut
- Georgetown University Hospital Research — Washington D.C., District of Columbia
- Georgetown University Hospital — Washington D.C., District of Columbia
- Nova Clinical Research LLC — Bradenton, Florida
- University of Florida — Gainesville, Florida
- Memorial Healthcare System — Hollywood, Florida
- Neurology Associates PA — Maitland, Florida
- Gables Neurology — Miami, Florida
- UM Department Of Neurology — Miami, Florida
- Aqualane Clinical Research — Naples, Florida
- Advent Health Orlando — Orlando, Florida
- Humanity Clinical Research — Pembroke Pines, Florida
- Emerald Coast Neurology — Pensacola, Florida
- Brain and Spine Institute — Port Orange, Florida
- Vero Beach Neurology — Vero Beach, Florida
- Conquest Research — Winter Park, Florida
- Methodist Neuroscience Institute — Merrillville, Indiana
- University of Kansas Hospital — Kansas City, Kansas
- Baptist Physicians Lexington — Nicholasville, Kentucky
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Relapsing Multiple Sclerosis
- A Study to Investigate the Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (RMS) — Fullerton, California
- A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone) — Cullman, Alabama
- Comparative PK, PD, Efficacy, and Safety Assessment of the Proposed Ocrelizumab Biosimilar CYB704 and Ocrevus in Participants With Relapsing Multiple Sclerosis — Maitland, Florida
- A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis. — Birmingham, Alabama
- A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) — Birmingham, Alabama
Explore by condition: All Relapsing Multiple Sclerosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.