De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia (NCT05213676)
Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The "NoNO Trial" - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established Collaborative
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation/stabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and/or mortality, as well as ECLS use, mortality, and/or oxygenation in congenital diaphragmatic hernia (CDH) newborns and to establish the cost-effectiveness of de-implementing iNO as a therapy in the postnatal resuscitation/stabilization phase of CDH management, which will be assessed as the incremental health system costs (savings) per prevented ECLS use and/or death.
Who can join: Review the eligibility criteria below.
Location: University of Alabama & Children's Hospital of Alabama (UAB-CoA) — Birmingham, Alabama
Age range: 0 Months to 1 Month
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- University of Alabama & Children's Hospital of Alabama (UAB-CoA) — Birmingham, Alabama
- University of Arkansas & Arkansas Children's Hospital (UA-ACH) — Little Rock, Arkansas
- University of California-Irvine & Children's Hospital of Orange County (UC-CHOC) — Irvine, California
- University of Southern California & Children's Hospital Los Angeles (USC-CHLA) — Los Angeles, California
- Stanford University & Lucile Packard Children's Hospital (Stanford-LPCH) — Palo Alto, California
- University of California, San Diego & Rady Children's Hospital (UCSD-Rady) — San Diego, California
- University of Colorado & Children's Hospital of Colorado (CU-CHC) — Aurora, Colorado
- Emory University & Children's Healthcare of Atlanta (CHOA) — Atlanta, Georgia
- Indiana University & Riley Children's Hospital (IU-RiCH) — Indianapolis, Indiana
- University of Louisville & Norton Children's Hospital (UL-NCH) — Louisville, Kentucky
- Harvard University & Boston Children's Hospital (Harvard-BCH) — Boston, Massachusetts
- University of Michigan & CS Mott Children's Hospital (UM-CSMott) — Ann Arbor, Michigan
- Randall Children's Hospital-Portland (RCH) — Portland, Oregon
- Medical University of South Carolina Children's Health (MUSC) — Charleston, South Carolina
- University of Tennessee & LeBonheur Children's Hospital (UT-LBCH) — Memphis, Tennessee
- Vanderbilt University & Vanderbilt University Medical Center (VUMC) — Nashville, Tennessee
- The University of Texas Health Science Center at Houston — Houston, Texas
- University of Utah & Primary Children's Hospital (Utah-PCH) — Salt Lake City, Utah
- University of Washington & Seattle Children's Hospital (UW-SCH) — Seattle, Washington
📞 Contact the Study Coordinator
Phone: (713) 500-7398
Email: Matthew.T.Harting@uth.tmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Congenital Diaphragmatic Hernia
- Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia — Houston, Texas
- Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Severe Left Diaphragmatic Hernia (CDH) — Baltimore, Maryland
- Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia — Philadelphia, Pennsylvania
- Infant Survival and Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia, A Phase III Trial — Kansas City, Missouri
- Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia — Portland, Oregon
- Fetoscopic Endoluminal Tracheal Occlusion — Aurora, Colorado
Explore by condition: All Congenital Diaphragmatic Hernia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.