WithHolding Enteral Feeds Around Blood Transfusion (International) (NCT05213806)
The WHEAT International Trial: WithHolding Enteral Feeds Around Red Cell Transfusion to Prevent Necrotizing Enterocolitis in Preterm Neonates: an International, Multi-centre, Randomized Controlled Trial
🩺 Plain-English Summary (8th-Grade Level)
The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (\<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize infants from Neonatal Intensive Care Units (NICUs) across Canada and the United Kingdom (UK) into one of the two care approaches (withholding or continued feeds) to determine if any significant outcomes are found.
Who can join: Review the eligibility criteria below.
Location: IWK Health — Halifax, Nova Scotia
Age range: Not specified to 30 Weeks
🧪 Interventions in This Study
- Withholding feeds around transfusion (OTHER)
- Continued feeds around transfusion (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (40 Sites)
Showing the first 25 of 40 sites.
- IWK Health — Halifax, Nova Scotia
- Norfolk & Norwich University Hospitals NHS Foundation Trust (Norfolk & Norwich University Hospital) — Norwich, England
- The Hillingdon Hospitals NHS Foundation Trust (Hillingdon Hospital) — Hillingdon, UK
- Barts Health NHS Trust (3 Hospitals: Royal London Hospital, Whipps Cross Hospital, Newham General Hospital) — London, UK
- Chelsea and Westminster Hospital NHS Foundation Trust (Chelsea and Westminster Hospital) — London, UK
- Imperial College Healthcare NHS Trust (2 Hospitals: St Mary's Hospital & Queen Charlotte's and Chelsea Hospital) — London, UK
- Bedfordshire Hospitals NHS Foundation Trust (Luton & Dunstable University Hospital) — Luton, UK
- East Kent University Hospitals NHS Foundation Trust (William Harvey Hospital) — Ashford,
- Buckinghamshire Healthcare NHS Trust (Stoke Mandeville Hospital) — Aylesbury,
- Barnsley Hospital NHS Foundation Trust — Barnsley,
- Birmingham Women's and Children's NHS Foundation Trust (Birmingham Women's Hospital NICU) — Birmingham,
- University Hospitals Birmingham NHS Trust (2 Hospitals: Heartland's Hospital & Good Hope Hospital) — Birmingham,
- Bradford Teaching Hospitals NHS Foundation Trust (Bradford Royal Infirmary) — Bradford,
- North Bristol NHS Trust (Southmead Hospital) — Bristol,
- East and North Essex NHS Foundation Trust - Colchester Hospital — Colchester,
- University Hospital Coventry & Warwickshire NHS Trust (University Hospital Coventry) — Coventry,
- University Hospitals of Derby and Burton NHS Trust (Royal Derby Hospital) — Derby,
- NHS Tayside (Ninewells Hospital) — Dundee,
- Medway Hospital NHS Foundation Trust (Oliver Fisher Neonatal Unit, Medway Maritime Hospital) — Gillingham,
- Gloucestershire Hospitals NHS Foundation Trust (Gloucestershire Royal Hospital) — Gloucester,
- Calderdale & Huddersfield NHS Foundation Trust (Calderdale Royal Hospital) — Halifax,
- East and North Essex NHS Foundation Trust - Ipswich Hospital — Ipswich,
- Leeds Teaching Hospitals NHS Trust (Leeds General Infirmary & St James' University Hospital) — Leeds,
- University Hospitals of Leicester NHS Trust (Leicester Royal Infirmary) — Leicester,
- Liverpool Women's Hospital NHS Foundation Trust (Liverpool Women's Hospital) — Liverpool,
📞 Contact the Study Coordinator
Phone: (902) 470-6630
Email: cari-lee.carnell@iwk.nshealth.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Necrotizing Enterocolitis
- IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study — Tucson, Arizona
- Early Predictors of Necrotizing Enterocolitis in Neonates — Columbus, Ohio
- RIC-NEC Randomized Controlled Trial — Cincinnati, Ohio
- A Cohort Study of the Intestinal Microbiota of Premature Infants — Sacramento, California
- Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC) — Little Rock, Arkansas
Explore by condition: All Necrotizing Enterocolitis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.