Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults (NCT05219617)
A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Carisbamate (YKP509) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults, With Optional Open-Label Extension
🩺 Plain-English Summary (8th-Grade Level)
The primary objective is to evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the number of drop seizures (tonic, atonic, and tonic-clonic) compared with placebo in pediatric and adult subjects (age 4-55 years) diagnosed with Lennox Gastaut Syndrome (LGS).
Who can join: Review the eligibility criteria below.
Location: Stanford University Hospital — Palo Alto, California
Age range: 4 Years to 55 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (71 Sites)
Showing the first 25 of 71 sites.
- Stanford University Hospital — Palo Alto, California
- University of Florida Health Science Center — Jacksonville, Florida
- AdventHealth — Orlando, Florida
- Pediatric Epilepsy and Neurology Specialists — Tampa, Florida
- University of South Florida — Tampa, Florida
- Axcess Medical Research — Wellington, Florida
- Consultants in Epilepsy and Neurology PLLC — Boise, Idaho
- Bluegrass Epilepsy Research, LLC — Lexington, Kentucky
- University Medical Center New Orleans — New Orleans, Louisiana
- Johns Hopkins Hospital — Baltimore, Maryland
- Mid-Atlantic Epilepsy and Sleep Center — Bethesda, Maryland
- Mayo Clinic — Rochester, Minnesota
- University of Missouri School of Medicine — Columbia, Missouri
- Northeast Regional Epilepsy Group — Hackensack, New Jersey
- St. Peters Hospital — New Brunswick, New Jersey
- Montefiore — The Bronx, New York
- Duke University Clinical Research at Pickett Road — Durham, North Carolina
- Wake Forest University - School of Medicine — Winston-Salem, North Carolina
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania
- Austin Epilepsy Care Center - Clinic/Outpatient Facility — Austin, Texas
- Neurology Consultants of Dallas, PA - Hospital — Dallas, Texas
- Virginia Epilepsy and Neurodevelopmental Clinic at WNC — Winchester, Virginia
- Hospital de Ninos de La Santisma Trinidad — Córdoba, Córdoba Province
- Resolution Psychopharmacology Research Institute — Mendoza, Mendoza Province
- Austin Hosptial — Heidelberg,
📞 Contact the Study Coordinator
Phone: (201) 421-3810
Email: bremes@sklsi.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.