A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (NCT05254743)
A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of Part 1 of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL; participants may or may not have already had treatment for their cancer. The purpose of Part 2 of this study evaluates pirtobrutinib monotherapy in treatment-naïve participants with CLL/SLL with 17p deletions. Participation could last up to six years for Part 1. Participation could last up to 2 years for Part 2.
Who can join: Review the eligibility criteria below.
Location: Pacific Cancer Medical Center, Inc — Anaheim, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (143 Sites)
Showing the first 25 of 143 sites.
- Pacific Cancer Medical Center, Inc — Anaheim, California
- TOI Clinical Research — Cerritos, California
- Stanford School of Medicine-Cancer Clinical Trials Office — Palo Alto, California
- California Cancer Associates for Research and Excellence — San Marcos, California
- Florida Cancer Specialists — Fort Myers, Florida
- Cancer Specialists of North Florida -St Augustine — Saint Augustine, Florida
- Florida Cancer Specialists East — West Palm Beach, Florida
- Hematology Oncology Clinic — Baton Rouge, Louisiana
- Tulane Cancer Center Office of Clinical Research — New Orleans, Louisiana
- American Oncology Partners of Maryland, PA — Bethesda, Maryland
- St. Vincent Frontier Cancer Center — Billings, Montana
- Cancer Care Associates Of York — York, Pennsylvania
- Prisma Health Cancer Institute — Greenville, South Carolina
- Sarah Cannon Research Institute SCRI — Nashville, Tennessee
- Kelsey Research Foundation — Houston, Texas
- Lumi Research — Kingwood, Texas
- Virginia Cancer Institute — Richmond, Virginia
- Medical Oncology Associates, PS — Spokane, Washington
- MultiCare Health System Institute for Research and Innovation — Spokane, Washington
- Alexander Fleming — Ciudad Autónoma de Buenos Aire,
- Hospital Privado De Comunidad — Mar del Plata,
- Clínica de Nefrología, Urología y Enfermedades Cardiovasculares — Santa Fe,
- One Clinical Research — Nedlands,
- Western Health, Sunshine Hospital — St Albans,
- The Perth Blood Institute — West Perth,
📞 Contact the Study Coordinator
Phone: (317) 615-4559
Email: LillyTrials@Lilly.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Chronic Lymphocytic Leukemia
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- Economic Analysis of Alliance A041202 CLL Study — Calgary, Alberta
- A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL — Chandler, Arizona
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Explore by condition: All Chronic Lymphocytic Leukemia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.