EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction (NCT05284747)
EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial Infarction
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic stroke, arterial revascularization, and all-cause death in subjects hospitalized for an acute myocardial infarction (non-ST-segment elevation myocardial infarction \[NSTEMI\] and ST-segment elevation myocardial infarction \[STEMI\]).
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years to 99 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (120 Sites)
Showing the first 25 of 120 sites.
- University of Alabama at Birmingham — Birmingham, Alabama
- Eastern Shore Research Institute — Fairhope, Alabama
- Heart Center Research LLC — Huntsville, Alabama
- Northern Arizona Healthcare Corporation Cardiovascular Institute — Flagstaff, Arizona
- Scottsdale Healthcare at Shea - HonorHealth — Scottsdale, Arizona
- Pima Heart and Vascular Clinical Research — Tucson, Arizona
- John Muir Health and Cardiovascular Institute — Concord, California
- VA Greater Los Angeles Healthcare System — Los Angeles, California
- University of California Los Angeles — Los Angeles, California
- University of California-Irvine — Orange, California
- University of Colorado Hospital — Aurora, Colorado
- Bridgeport Hospital — Bridgeport, Connecticut
- Hartford Hospital — Hartford, Connecticut
- Cardiology Associates of Fairfield County PC — Stamford, Connecticut
- Excel Medical Clinical Trials — Boca Raton, Florida
- Clearwater Cardiovascular Consultants — Clearwater, Florida
- University of Florida at Gainesville — Gainesville, Florida
- University of Florida and Shands Hospital — Jacksonville, Florida
- AdventHealth Orlando — Orlando, Florida
- Cardiology Partners Clinical Research Institute — Palm Beach Gardens, Florida
- Baptist Health Care — Pensacola, Florida
- Ascension Sacred Heart — Pensacola, Florida
- Clearwater Cardiovascular Consultants — Safety Harbor, Florida
- Tampa Cardiovascular Interventions and Research — Tampa, Florida
- Clinical Site Partners Orlando dba Flourish Research — Winter Park, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cardiovascular Disease
- Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors — Québec,
- Hispanic Community Health Study / Study of Latinos — Chapel Hill, North Carolina
- Nitric Oxide Bioavailability and Early Life Stress (NO-Stress) — Augusta, Georgia
- Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease — Houston, Texas
- Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction — Los Angeles, California
Explore by condition: All Cardiovascular Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.