๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-15

A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer) (NCT05288166)

CYCLONE 3: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Abemaciclib in Combination With Abiraterone Plus Prednisone in Men With High-Risk Metastatic Hormone-Sensitive Prostate Cancer

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Eli Lilly and Company

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse. Participation may last approximately 60 months.

Who can join: Review the eligibility criteria below.

Location: Arizona Oncology Associates, P.C. - HOPE โ€” Prescott, Arizona

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (266 Sites)

Showing the first 25 of 266 sites.

  • Arizona Oncology Associates, P.C. - HOPE โ€” Prescott, Arizona
  • Arizona Oncology Associates, P.C. - HOPE โ€” Prescott Valley, Arizona
  • The University of Arizona Cancer Center - North Campus โ€” Tucson, Arizona
  • Genesis Cancer and Blood Institute โ€” Hot Springs, Arkansas
  • St. Bernards Medical Center โ€” Jonesboro, Arkansas
  • Highlands Oncology Group โ€” Springdale, Arkansas
  • Orange Coast Memorial Medical Center โ€” Fountain Valley, California
  • Providence Medical Foundation โ€” Fullerton, California
  • Moores Cancer Center โ€” La Jolla, California
  • MemorialCare Health System - Long Beach Medical Center โ€” Long Beach, California
  • Cancer and Blood Specialty Clinic โ€” Los Alamitos, California
  • UCLA Hematology/Oncology - Santa Monica โ€” Los Angeles, California
  • Torrance Memorial Physician Network / Cancer Care โ€” Torrance, California
  • PIH Health Hematology Medical Oncology โ€” Whittier, California
  • University of Colorado Anschutz Medical Campus โ€” Aurora, Colorado
  • UCHealth Memorial Hospital โ€” Colorado Springs, Colorado
  • UCHealth Harmony โ€” Fort Collins, Colorado
  • Colorado West Healthcare System - Grand Valley Oncology โ€” Grand Junction, Colorado
  • USO-Rocky Mountain Cancer Center โ€” Littleton, Colorado
  • Florida Cancer Specialists - South โ€” Fort Myers, Florida
  • Memorial Regional Hospital โ€” Hollywood, Florida
  • Millennium Oncology Research Clinic โ€” Hollywood, Florida
  • University of Miami Hospital and Clinics, Sylvester Cancer Center โ€” Miami, Florida
  • Florida Cancer Specialist- East โ€” West Palm Beach, Florida
  • Dwight D Eisenhower Army Medical Center โ€” Fort Gordon, Georgia

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—