Angiotensin-(1-7) Cardiovascular Effects in Aging (NCT05301192)
๐ฉบ Plain-English Summary (8th-Grade Level)
Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood. One hallmark of aging is an increase in sympathetic nervous system activity, which can decrease the number and/or sensitivity of ฮฒ2 adrenergic receptors to reduce dilation of blood vessels and increase blood pressure. Identifying new targets to restore vascular ฮฒ2 adrenergic receptor signaling may help reduce cardiovascular risk in aging. This study will test the hypothesis that angiotensin-(1-7), a protective hormone of the renin-angiotensin system, can reduce cardiovascular sympathetic outflow and blood pressure and improve endothelial function in older healthy humans.
Who can join: Review the eligibility criteria below.
Location: Penn State Milton S. Hershey Medical Center โ Hershey, Pennsylvania
Age range: 65 Years to 80 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (1 Sites)
- Penn State Milton S. Hershey Medical Center โ Hershey, Pennsylvania
๐ Contact the Study Coordinator
Phone: (717) 531-1617
Email: acauffman@pennstatehealth.psu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aging
- A Pilot Study on Reverse Aging (The REVERSE Study) โ Cincinnati, Ohio
- Feasibility of Home-based tES for Older Adults at Risk of Falling โ Roslindale, Massachusetts
- Heat, Microvascular Function and Aging โ Milwaukee, Wisconsin
- Protein Quantity and Quality in Older Subjects โ Hamilton, Ontario
- Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse โ Salt Lake City, Utah
- Effect of a Daily Supplement on Plasma PAI-1 Levels โ Los Angeles, California
Explore by condition: All Aging clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.