๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-04

Cardiac Outcomes With Near-Complete Estrogen Deprivation (NCT05309655)

The Cardiac Outcomes With Near-Complete Estrogen Deprivation (CROWN) Study

๐Ÿ”ต Active, Not Recruiting Observational / Diagnostic ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Duke University

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this research study is to understand what effect near complete estrogen deprivation (NCED) therapy has on the heart in breast cancer patients. Investigators want to understand if NCED changes how the heart works.

Who can join: Review the eligibility criteria below.

Location: Duke Cancer Center โ€” Durham, North Carolina

Age range: 18 Years to 55 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (3 Sites)

  • Duke Cancer Center โ€” Durham, North Carolina
  • Wake Forest Baptist Comprehensive Cancer Center โ€” Winston-Salem, North Carolina
  • Virginia Commonwealth University Massey Cancer Center โ€” Richmond, Virginia

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Breast Cancer clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—