🏛️ Verified NIH Record • Updated 2026-08-14
Gyrate Atrophy Ocular and Systemic Study (NCT05312736)
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Jaeb Center for Health Research
🩺 Plain-English Summary (8th-Grade Level)
The Gyrate Atrophy Ocular and Systemic Study characterizes the natural history of ornithine levels and retinal degeneration (RD) associated with disease-causing OAT variants in the presence of standard care dietary treatment regimens over 4 years. The research goal is to understand the impact of OAT mutations on plasma ornithine levels and retinal degeneration. Funding Source- FDA OOPD
Who can join: Review the eligibility criteria below.
Location: University of California San Francisco — San Francisco, California
Age range: 12 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- University of California San Francisco — San Francisco, California
- Johns Hopkins University, Wilmer Eye Institute — Baltimore, Maryland
- Harvard Univ., Massachusetts Eye and Ear Infirmary — Boston, Massachusetts
- University of Pennsylvania — Philadelphia, Pennsylvania
- INRET Clínica e Centro de Pesquisa — Belo Horizonte, Minas Gerais
- University of Toronto, Hospital for Sick Children — Toronto, Ontario
- Helsinki University Hospital — Helsinki,
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC1423 — Paris,
- University of Tuebingen, Centre for Ophthalmology — Tübingen,
- Vista Vision Eye Clinic — Brescia,
- Moorfields Eye Hospital — London,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Gyrate Atrophy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.