Who is eligible for clinical trial NCT05329766?

Participants must meet protocol criteria for Gastrointestinal Tract Malignancies. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT05329766 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-07-28

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies (NCT05329766)

A Phase 2 Trial to Evaluate the Safety and Efficacy of Combination Therapies in Patients With Advanced Upper Gastrointestinal Tract Malignancies (EDGE-Gastric)

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Arcus Biosciences, Inc.

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the safety and preliminary clinical activity of treatment combinations with and without chemotherapy in participants with locally advanced unresectable or metastatic gastric, GEJ, and esophageal adenocarcinoma. Chemotherapy will consist of FOLFOX (oxaliplatin, leucovorin, fluorouracil).

Who can join: Review the eligibility criteria below.

Location: Research Site — Phoenix, Arizona

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (43 Sites)

Showing the first 25 of 43 sites.

Research Site — Phoenix, Arizona
Research Site — Los Angeles, California
Research Site — Santa Monica, California
Research Site — Derby, Connecticut
Research Site — Fort Myers, Florida
Research Site — Jacksonville, Florida
Research Site — St. Petersburg, Florida
Research Site — Boston, Massachusetts
Research Site — New York, New York
Research Site — New York, New York
Research Site — Durham, North Carolina
Research Site — Columbus, Ohio
Research Site — Oklahoma City, Oklahoma
Research Site — Portland, Oregon
Research Site — Nashville, Tennessee
Research Site — Nashville, Tennessee
Research Site — Fairfax, Virginia
Research Site — Toronto,
Research Site — Las Condes,
Research Site — Recoleta,
Research Site — Santiago,
Research Site — Talca,
Research Site — Bordeaux,
Research Site — Brest,
Research Site — Caen,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Gastrointestinal Tract Malignancies clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗