Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome (NCT05344599)
Estimating the Frequency and Neuro-Hormonal Characteristics of Acute Hepatic Porphyria in Postural Tachycardia Syndrome
🩺 Plain-English Summary (8th-Grade Level)
Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women. The condition is characterized by a rapid increase in heart rate (HR) that occurs on standing, and chronic symptoms of cerebral hypoperfusion leading to lightheadedness, dizziness, and blurred vision. The acute hepatic porphyrias(AHP)are among the diseases that present with autonomic cardiovascular(tachycardia)and neurovisceral symptoms (abdominal pain) among others; they present with acute exacerbations Given that there is available treatment for AHP that change the natural progression of the disease, study focuses to investigate the occurrence of AHP in POTS and determine the clinical and neuro-hormonal characteristic of the POTS subgroup that will likely benefit from AHP screening. This study has one visit that involves, answering some questionnaires, coming to the lab for blood work, genetic testing, and some autonomic function tests. About 50 people will take part in this study.
Who can join: Review the eligibility criteria below.
Location: Vanderbilt University Medical Center — Nashville, Tennessee
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
- Autonomic Function Testing (DIAGNOSTIC_TEST)
- Genetic Testing (DIAGNOSTIC_TEST)
- Urine Testing (DIAGNOSTIC_TEST)
- Blood laboratory Testing (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Vanderbilt University Medical Center — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Postural Orthostatic Tachycardia Syndrome
- Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome — Nashville, Tennessee
- Transdermal Vagal Stimulation for POTS — Nashville, Tennessee
- Compression Garments in the Community With POTS — Calgary, Alberta
- CAlgary SAlt for POTS — Calgary, Alberta
- Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS) — Dallas, Texas
Explore by condition: All Postural Orthostatic Tachycardia Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.