๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-25

Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer (NCT05367440)

A Multi-arm, Open-label Phase I/IIa Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of AZD5305 in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer (PETRANHA)

๐Ÿ”ต Active, Not Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: AstraZeneca

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of AZD5305 when given in combination with new hormonal agents (NHAs) in patients with Metastatic Prostate Cancer.

Who can join: Review the eligibility criteria below.

Location: Research Site โ€” Detroit, Michigan

Age range: 18 Years to 130 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (20 Sites)

  • Research Site โ€” Detroit, Michigan
  • Research Site โ€” Detroit, Michigan
  • Research Site โ€” Syracuse, New York
  • Research Site โ€” Myrtle Beach, South Carolina
  • Research Site โ€” Houston, Texas
  • Research Site โ€” Houston, Texas
  • Research Site โ€” Camperdown,
  • Research Site โ€” Darlinghurst,
  • Research Site โ€” East Melbourne,
  • Research Site โ€” Heidelberg,
  • Research Site โ€” Melbourne,
  • Research Site โ€” St Leonards,
  • Research Site โ€” Candiolo,
  • Research Site โ€” Milan,
  • Research Site โ€” Orbassano,
  • Research Site โ€” Padova,
  • Research Site โ€” Cambridge,
  • Research Site โ€” Glasgow,
  • Research Site โ€” Manchester,
  • Research Site โ€” Plymouth,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—