A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02) (NCT05374512)
A Phase 3, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) Versus Investigator's Choice of Chemotherapy in Patients Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy in First-line Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION Breast02)
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase III, randomised, open-label, 2 arm, multicentre, international study assessing the efficacy and safety of Dato-DXd compared with ICC in participants with locally recurrent inoperable or metastatic TNBC who are not candidates for PD-1/PD-L1 inhibitor therapy.
Who can join: Review the eligibility criteria below.
Location: Research Site — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (228 Sites)
Showing the first 25 of 228 sites.
- Research Site — Duarte, California
- Research Site — Los Angeles, California
- Research Site — San Francisco, California
- Research Site — Grand Junction, Colorado
- Research Site — Longmont, Colorado
- Research Site — New Haven, Connecticut
- Research Site — Washington D.C., District of Columbia
- Research Site — Miami, Florida
- Research Site — Miami, Florida
- Research Site — Atlanta, Georgia
- Research Site — Louisville, Kentucky
- Research Site — Detroit, Michigan
- Research Site — Albuquerque, New Mexico
- Research Site — New York, New York
- Research Site — Charlotte, North Carolina
- Research Site — Winston-Salem, North Carolina
- Research Site — Providence, Rhode Island
- Research Site — Sioux Falls, South Dakota
- Research Site — Memphis, Tennessee
- Research Site — Nashville, Tennessee
- Research Site — Fort Worth, Texas
- Research Site — Houston, Texas
- Research Site — Kingwood, Texas
- Research Site — San Antonio, Texas
- Research Site — Charlottesville, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.