Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI (NCT05377177)
Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression (COMBAT-SI)
🩺 Plain-English Summary (8th-Grade Level)
This is a prospective clinical trial to confirm the effectiveness of bilateral accelerated theta burst stimulation (aTBS) on suicidal ideation (SI), while exploring cortical inhibition measures in this treatment paradigm. In this proposed study, the investigators will evaluate the anti-suicidal effects of bilateral aTBS over the DLPFC compared to accelerated intermittent theta burst stimulation (aiTBS) over the left DLPFC in participants with TRD and SI. Additionally, the investigators aim to identify neurophysiological targets through which bilateral aTBS induces remission of SI in TRD differentially from aiTBS.
Who can join: Review the eligibility criteria below.
Location: UCSD Interventional Psychiatry — San Diego, California
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UCSD Interventional Psychiatry — San Diego, California
📞 Contact the Study Coordinator
Phone: (858) 657-6152
Email: iptrials@health.ucsd.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Suicidal Ideation
- Dynamic Deconstructive Psychotherapy Versus Brief Intervention and Contact for Suicidal Adolescents and Young Adults — Syracuse, New York
- The Group Risk Reduction Intervention Therapy (GRRIT) Project — Portsmouth, Virginia
- A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior — Boston, Massachusetts
- Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial — Cleveland, Ohio
- Neural Correlates of Suicidal Behavior in Youth — Cleveland, Ohio
- Task-Shifting Adapted IPT-A for Youth Suicide Prevention — Chestnut Hill, Massachusetts
Explore by condition: All Suicidal Ideation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.