Adenosine 2A Receptor Antagonism and AIH in ALS (NCT05377424)
Acute Adenosine Receptor Antagonism to Promote Breathing Plasticity in ALS
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this research study is to determine the effects of a medication, istradefylline, in conjunction with breathing air with reduced oxygen for short periods of time (called acute intermittent hypoxia, or AIH), on breathing. This project will study breathing in people with amyotrophic lateral sclerosis (ALS) and unaffected, age-matched adults. Istradefylline is prescribed to increase movement in people with other neuromuscular conditions. A recently completed study found that people with ALS took deeper breaths, 60 minutes after using AIH.
Who can join: Review the eligibility criteria below.
Location: Clinical and Translational Research Building — Gainesville, Florida
Age range: 21 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Clinical and Translational Research Building — Gainesville, Florida
- UF Health Jacksonville — Jacksonville, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in ALS
- Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS) — Scottsdale, Arizona
- ALS/MND Natural History Study Data Repository — Loma Linda, California
- NYSCF Scientific Discovery Biobank — New York, New York
- Combined Respiratory Training in Persons With ALS — Fort Lauderdale, Florida
- ECoG BMI for Motor and Speech Control — San Francisco, California
Explore by condition: All ALS clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.