🏛️ Verified NIH Record • Updated 2025-09-16
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382286)
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Gilead Sciences
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).
Who can join: Review the eligibility criteria below.
Location: Alaska Oncology and Hematology — Anchorage, Alaska
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (504 Sites)
Showing the first 25 of 504 sites.
- Alaska Oncology and Hematology — Anchorage, Alaska
- Arizona Oncology Associates, PC-Hope,1845 W Orange Grove Rd — Tucson, Arizona
- Arizona Oncology Associates, PC-Hope,2070 W. Rudasill Rd. — Tucson, Arizona
- Arizona Oncology Associates, PC-Hope — Tucson, Arizona
- Arizona Oncology Associates, PC-Hope,1620 West St. Mary's Road — Tucson, Arizona
- Genesis Cancer and Blood Institute — Hot Springs, Arkansas
- Genesis Cancer and Blood Institute,1456 Higdon Ferry Road Suite B. — Hot Springs, Arkansas
- Saint Bernards Medical Center — Jonesboro, Arkansas
- Saint Bernards Medical Center,4000 Linwood Drive — Paragould, Arkansas
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,201 S. Buena Vista Street, Suite 200 — Burbank, California
- University of California Irvine Health Chao Family,1640 Newport Blvd — Costa Mesa, California
- City of Hope — Duarte, California
- University of California San Diego Moores Cancer — La Jolla, California
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,24302 Paseo de Valencia, Suite 200 — Laguna Hills, California
- Cancer and Blood Specialty Clinic — Los Alamitos, California
- City of Hope,1601 Avocado Ave — Newport, California
- University of California Irvine Health Chao Family — Orange, California
- City of Hope,209 Fair Oaks Ave — Pasadena, California
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,892 Aerovista Place, Suite 240 — San Luis Obispo, California
- Sansum Clinic — Santa Barbara, California
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,2020 Santa Monica Blvd, Suite 600 — Santa Monica, California
- University of California Los Angeles - Jonsson Comprehensive Cancer Center,2336 Santa Monica, Suites 302 and 304 — Santa Monica, California
- University of California Los Angeles - Jonsson Comprehensive Cancer Center — Santa Monica, California
- St. Jude Hospital Yorba dba St. Joseph Heritage Healthcare — Santa Rosa, California
- Sansum Clinic,2040 Viborg Road — Solvang, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Triple Negative Breast Cancer
- Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer — Tucson, Arizona
- Comparison of the Breast Tumor Microenvironment — New York, New York
- Phase 2 Trial of Neoadjuvant Weekly Carboplatin Plus Paclitaxel in Triple Negative Breast Cancer — Chicago, Illinois
- Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo — Mobile, Alabama
- Ribociclib and Bicalutamide in AR+ TNBC — Chicago, Illinois
- Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC — La Jolla, California
Explore by condition: All Triple Negative Breast Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.