Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia (NCT05386394)
Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
🩺 Plain-English Summary (8th-Grade Level)
While many have strongly suggested that transcranial direct current stimulation (tDCS) may represent a beneficial intervention for patients with primary progressive aphasia (PPA), this promising technology has not yet been applied widely in clinical settings. This treatment gap is underscored by the absence of any neurally-focused standard-of-care treatments to mitigate the devastating impact of aphasia on patients' family, work, and social lives. Given that tDCS is inexpensive, easy to use (it is potentially amenable to home use by patients and caregivers), minimally invasive, and safe there is great promise to advance this intervention toward clinical use. The principal reason that tDCS has not found wide clinical application yet is that its efficacy has not been tested in large, multi-center, clinical trials. In this study, scientists in the three sites that have conducted tDCS clinical trials in North America-Johns Hopkins University and the University of Pennsylvania in the US, and the University of Toronto in Canada, will collaborate to conduct a multi-site, Phase II clinical trial of tDCS a population in dire need of better treatments.
Who can join: Review the eligibility criteria below.
Location: Johns Hopkins Hospital — Baltimore, Maryland
Age range: 50 Years to 90 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Johns Hopkins Hospital — Baltimore, Maryland
- University of Pennsylvania — Philadelphia, Pennsylvania
- Baycrest Centre for Geriatric Care — Toronto, Ontario
📞 Contact the Study Coordinator
Phone: (410) 929-0279
Email: krmeun@jhmi.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Primary Progressive Aphasia
- Treatment for Speech and Language in Primary Progressive Aphasia — San Francisco, California
- Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation — Dallas, Texas
- Communication Bridge Pilot Study — Chicago, Illinois
- Language in Primary Progressive Aphasia — Chicago, Illinois
- Stimulating the Aging Brain Using Brain and Sensory Stimulation — Milwaukee, Wisconsin
- Enhancing Language Function in Primary Progressive Aphasia — Tucson, Arizona
Explore by condition: All Primary Progressive Aphasia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.